19396-06-6

• 常用中文名：多抗霉素
• 常用英文名：POLYOXIN B
• CAS号：19396-06-6
• 分子式：C₁₇H₂₅N₅O₁₃
• 分子量：507.40600
• 相关类别： 原料药 抗生素类药物 农用抗生素
• 发布时间：2018-02-07 08:00:00
• 更新时间：2026-07-07 20:39:30
• 【用途1】
  广谱性抗菌素类杀菌剂，具有内吸传导作用。其作用机制是干扰细胞壁壳多糖的生物合成。以壳多糖为基质而构成细胞壁的子囊菌纲、担子菌纲和半知菌纲的一些真菌，芽管和菌丝体接触药剂后会局部膨大、破裂、溢出细胞内含物，导致死亡。主要用于防治小麦白粉病，人参黑斑病，烟草赤星病，黄瓜霜霉病，瓜类枯萎病，水稻纹枯病，苹果斑点落叶病，草莓及葡萄灰霉病，林木枯鞘病等多种真菌病害。如用宝丽安10%可湿性粉剂1000～2000倍液可防治小麦白粉病和水稻纹枯病，若用量15～22.5g/100m²在花开期开始喷药，可防治番茄、草莓等作物的灰霉病，以后隔7d喷1次，共3～4次。对苹果斑点落叶病，在苹果春梢生长期、发病盛期，用50～100mg/L多抗霉素溶液喷雾。

名称

• 中文名: 多抗霉素
• 英文名: polyoxin b
• 中文别名: 标准物质/水中多抗霉素(B型)/GB 26; 多抗霉素B 标准品; 甲醇/水中多抗霉素 B 溶液,100ΜG/ML; 科生霉素; (S)-2-((2S,3S,4S)-2-氨基-5-(氨基甲酰氧基)-3,4-二羟基戊酰胺)-2-((2R,3S,4R,5R)-3,4-二羟基-5-(5-(羟甲基)-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-2-基)乙酸; 5-[[2-氨基-5-O-(氨基羰基)-2-脱氧-L-木糖基]氨基]-1,5-二脱氧-1-[3,4-二氢-5-(羟基甲基)-2,4-二氧代-1(2H)-嘧啶基]-β-D-另呋喃糖醛酸; 特卖【供应】纯天然 多抗霉素 B(低纯度不足) 19-6; 多氧霉素、多效霉素、多氧清; 多抗霉素原药; 多克菌; 灭腐灵; 多抗霉素 B溶液,1000PPM; 宝丽安; 水中多抗霉素(B型)/GB 26; 水中多抗霉素B溶液; 多效霉素; 多抗霉素19-6; 水中多抗霉素B溶液标准物质; 多氧霉素; 多抗霉素母药; 多抗霉素 B(低纯度不足); 肽嘧啶核苷; 多氧霉素B; 保利霉素; 多抗菌素B; 保利霉素 B; 5-[[2-氨基-5-O-(氨基羰基)-2-脱氧-L-木糖基]氨基]-1,5-二脱氧-1-[3,4-二氢-5-(羟基甲基)-2,4-二氧代-1(2H)-嘧啶基]-Β-D-别呋喃糖醛酸; 5-((2-氨基-5-O-(氨基羰基)-2-脱氧-L-木糖基)氨基)-1,5-二脱氧-1-(3,4-二氢-5-(羟基甲基)-2,4-二氧代-1(2H)-嘧啶基)-Β-D-别呋喃糖醛酸; 多抗霉素9-6; 多抗霉素B; 多氧菌素 B
• 英文别名: β-D-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]; ro-5-(hydroxymethyl)-2,4-dioxo-1(2h)-pyrimidinyl)-,monocbamate(ester),bet; Polyoxin B Solution in Methanol/Water, 100μg/mL; (S)-2-((2S,3S,4S)-2-Amino-5-(cbamoyloxy)-3,4-dihydroxypentanamido)-2-((2R,3S,4R,5R)-3,4-dihydroxy-5-(5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)acetic acid; POLYOXIN B //BP; 5-[[2-amino-5-o-(aminocbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronicacid; b-D-Allofuranuronic acid,5-[[2-amino-5-O-(aMinocbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxyMethyl)-2,4-dioxo-1(2H)-pyriMidinyl]; polyoxinal; piomycin; 5-(2-amino-5-o-cbamoyl-2-deoxy-l-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1-(2h)-pyrimidinyl)-beta-d-allofuranuronicacid; ro-5-(hydroxymethyl)-2,4-dioxo-1(2h); 5-[(2-Amino-5-O-cbamoyl-2-deoxy-L-xylonoyl)amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid; 5-[[2-Amino-5-O-(aminocbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid; allofuranuronicacid,5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihyd; 5-[2-Amino-5-O-(aminocbonyl)-2-deoxy-L-xylos-1-ylamino]-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid; Polyoxin AL; Polyoxin B（）; 5-(2-amino-5-O-cbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid; 5-[[2-amino-5-o-(aminocbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronic acid; POLYXIN; Polyoxin B in Water; 5-{[2-amino-5-O-(aminocbonyl)-2-deoxy-L-xylonoyl] amino}-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimnidinyl]-β-D-allofur-a-nuronic acid; polyoxin AL(JMAF); polyoxin(JMAF); POLYOXIN B Solution, 1000ppm

物化性质

• 密度: 1.774 g/cm3
• 分子式: C₁₇H₂₅N₅O₁₃
• 分子量: 507.40600
• 精确质量: 507.14500
• PSA: 309.98000
• 折射率: 1.669
• 储存条件: 2-8°C，避光，保存于惰性气体中
• 稳定性:

  原药为浅褐色粉末。易溶于水，不溶于有机溶剂。对紫外线稳定，在酸性和中性溶液中稳定，但在碱性溶液中不稳定。

• 分子结构:

  1、 摩尔折射率：106.73

  2、 摩尔体积（cm³/mol）：285.9

  3、 等张比容（90.2K）：930.5

  4、 表面张力（dyne/cm）：112.1

  5、 极化率（10-24cm3）：42.31

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BA2927000 CHEMICAL NAME : Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-d ihydro-5- (hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-, monocarbamate (ester), beta-D- CAS REGISTRY NUMBER : 19396-06-6 LAST UPDATED : 199204 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C17-H25-N5-O13 MOLECULAR WEIGHT : 507.47 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14665 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C244,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,696,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15638 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C244,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,245,1981

安全

• 海关编码: 2934999031

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制备

以黄豆饼粉、饴糖、酵母粉、玉米粉为原料，采用纯种液体深层发酵制得。

海关

海关编码	2934999031