64318-79-2

• 常用中文名：吉美前列素
• 常用英文名：gemeprost
• CAS号：64318-79-2
• 分子式：C₂₃H₃₈O₅
• 分子量：394.545
• 相关类别： 原料药 激素及调节内分泌功能类药 前列腺素类药
• 发布时间：2018-06-26 12:28:06
• 更新时间：2024-01-14 11:08:31

名称

• 中文名: 吉美前列素
• 英文名: gemeprost
• 英文别名: ONO 802; Cergem; Methyl (2E,11α,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-2,13-dien-1-oate; Methyl (E)-7-((1R,2R,3R)-3-hydroxy-2-((E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl)-5-oxocyclopentyl)-2-heptenoate; (2E,11a,13E,15R)-11,15-Dihydroxy-16-16-dimethyl-9-oxoprosta-2,13-dien-1-oic Acid Methyl Ester; gemeprost; Cervageme; Carprost; Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, methyl ester, (2E,11α,13E,15R)-; 16,16-Dimethyl-trans-D2-PGE1 Methyl Ester; Cervagem; Preglandin

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 510.5±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₈O₅
• 分子量: 394.545
• 闪点: 163.9±23.6 °C
• 精确质量: 394.271912
• PSA: 83.83000
• LogP: 3.48
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.533
• 储存条件: 库房低温通风干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UK7894500 CHEMICAL NAME : Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, methyl ester, (2E,11-alpha,13E,15R)- CAS REGISTRY NUMBER : 64318-79-2 LAST UPDATED : 199709 DATA ITEMS CITED : 25 MOLECULAR FORMULA : C23-H38-O5 MOLECULAR WEIGHT : 394.61 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 56500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22600 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28600 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravaginal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 32500 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32500 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravaginal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 36 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 187500 ug/kg/30D-C TOXIC EFFECTS : Gastrointestinal - other changes Liver - changes in liver weight Blood - changes in leukocyte (WBC) count REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7500 ug/kg/30D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in spleen weight Blood - normocytic anemia REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,188,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 86 ug/kg SEX/DURATION : female 14 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 91,1136,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 20 ug/kg SEX/DURATION : female 31 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 96,745,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 20 ug/kg SEX/DURATION : female 10 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 27,51,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 20 ug/kg SEX/DURATION : female 10 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 27,339,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 4 mg/kg SEX/DURATION : female 2 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 79,15,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 4 mg/kg SEX/DURATION : female 17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 79,15,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 79,15,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 80 ug/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,593,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 438 ug/kg SEX/DURATION : female 1-7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,809,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 438 ug/kg SEX/DURATION : female 1-7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,809,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 5 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 4,233,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 2 mg/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : GEIRDK Gendai Iryo. Modern Medical Care. (Towa Bldg., 2-7 Nishiki-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1969- Volume(issue)/page/year: 14,593,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 4 mg/kg SEX/DURATION : female 6-7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 79,15,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 200 ug/kg SEX/DURATION : female 24-25 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 79,15,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 162 ug/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 4,225,1984

安全

• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)