85622-95-3

• 常用中文名：米托唑胺
• 常用英文名：Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,3-(2-chloroethyl)-3,4-dihydro-4-oxo-
• CAS号：85622-95-3
• 分子式：C₇H₇ClN₆O₂
• 分子量：242.62200
• 发布时间：2018-08-29 14:38:35
• 更新时间：2024-01-10 19:43:15

名称

• 中文名: 米托唑胺
• 英文名: 3-(2-chloroethyl)-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
• 英文别名: Azolastone; Mitozolamide; Mitozolomide

物化性质

• 密度: 1.94g/cm3
• 沸点: 555.8ºC at 760 mmHg
• 分子式: C₇H₇ClN₆O₂
• 分子量: 242.62200
• 闪点: 289.9ºC
• 精确质量: 242.03200
• PSA: 108.17000
• 折射率: 1.834

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ5927000 CHEMICAL NAME : Imidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo- CAS REGISTRY NUMBER : 85622-95-3 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C7-H7-Cl-N6-O2 MOLECULAR WEIGHT : 242.65 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 3108 ug/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified) TYPE OF TEST : LD10 - Lethal Dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Blood - changes in cell count (unspecified) Blood - changes in bone marrow (not otherwise specified) Tumorigenic - active as anti-cancer agent TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 40 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 50 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1767,1984

合成路线

1943-83-5 360-97-4 ~% 85622-95-3

文献：US2012/283280 A1, ; Page/Page column 6-7 ;

1943-83-5 7008-85-7 ~95% 85622-95-3

文献：Stevens, Malcolm F. G.; Hickman, John A.; Stone, Robert; Gibson, Neil W.; Baig, Ghouse Unissa; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 196 - 201

188612-57-9 ~72% 85622-95-3

文献：Wang, Yongfeng; Wheelhouse, Richard T.; Zhao, Linxiang; Langnel, David A. F.; Stevens, Malcolm F. G. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1669 - 1675

1943-83-5 40784-02-9 ~94% 85622-95-3

文献：Lowe, Philip R.; Schwalbe, Carl H.; Stevens, Malcolm F.G. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 357 - 362

上下游产品

上游产品  5
1943-83-5 360-97-4 7008-85-7 188612-57-9
40784-02-9
下游产品  9
360-97-4 28177-14-2 107-07-3 113960-08-0
85622-96-4 85623-00-3 78695-87-1 78695-90-6
40784-02-9