6879-02-3

• 常用中文名：娃兒藤鹼
• 常用英文名：Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline,9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-, (13aR)-
• CAS号：6879-02-3
• 分子式：C₂₄H₂₇NO₄
• 分子量：393.47500
• 发布时间：2018-08-24 17:18:44
• 更新时间：2024-01-15 21:16:18

名称

• 中文名: 娃兒藤鹼
• 英文名: Tylocrebrine
• 英文别名: Tylocerebrine; [13aR,(+)]-9,11,12,13,13a,14-Hexahydro-2,3,5,6-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline; (-)-(R)-tylocrebrine; Tylocrebrin; Dibenzo(F,H)pyrrolo(1,2-B)isoquinoline,9,11,12,13,13A,14-hexahydro-2,3,5,6-tetramethoxy-,(R)-(9ci); Dibenzo(F,H)pyrrolo(1,2-B)isoquinoline,9,11,12,13,13A,14-hexahydro-2,3,5,6-tetramethoxy; Lylocrebrine; Tylocrebine

物化性质

• 密度: 1.26g/cm3
• 沸点: 559.9ºC at 760 mmHg
• 分子式: C₂₄H₂₇NO₄
• 分子量: 393.47500
• 闪点: 160.5ºC
• 精确质量: 393.19400
• PSA: 40.16000
• LogP: 4.48580
• 蒸汽压: 1.44E-12mmHg at 25°C
• 折射率: 1.657

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YP0175000 CHEMICAL NAME : Tylocrebrine CAS REGISTRY NUMBER : 6879-02-3 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C24-H27-N-O4 MOLECULAR WEIGHT : 393.52 WISWESSER LINE NOTATION : T D5 B6 K666 DNJ MO1 NO1 RO1 SO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 12 mg/kg/24D-I TOXIC EFFECTS : Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - ulceration or bleeding from large intestine Blood - other changes REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 24 mg/kg/24D-I TOXIC EFFECTS : Liver - other changes Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964

合成路线

1260216-15-6 ~63% 6879-02-3

文献：Niphakis, Micah J.; Georg, Gunda I. Organic Letters, 2011 , vol. 13, # 2 p. 196 - 199

1260216-09-8 ~% 6879-02-3

文献：Niphakis, Micah J.; Georg, Gunda I. Organic Letters, 2011 , vol. 13, # 2 p. 196 - 199

89978-46-1 ~% 6879-02-3

文献：Niphakis, Micah J.; Georg, Gunda I. Organic Letters, 2011 , vol. 13, # 2 p. 196 - 199

40972-86-9 ~% 6879-02-3

文献：Niphakis, Micah J.; Georg, Gunda I. Organic Letters, 2011 , vol. 13, # 2 p. 196 - 199

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