486-17-9

• 常用中文名：卡普托胺
• 常用英文名：captodiame
• CAS号：486-17-9
• 分子式：C₂₁H₂₉NS₂
• 分子量：359.59200
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-01-19 18:58:13

名称

• 中文名: 卡普托胺
• 英文名: 2-[(4-butylsulfanylphenyl)-phenylmethyl]sulfanyl-N,N-dimethylethanamine
• 英文别名: N,N-Dimethyl-2-(4-butylmercapto-benzhydrylmercapto)-ethylamin; Captodiamin; Kaptodiamin [Czech]; Captodiamine; [2-(4-Butylmercapto-benzhydrylmercapto)-aethyl]-dimethyl-amin; Captodramine; Captodiame; Covatin; Captodramin; Captodiamum [INN-Latin]; Captodiamo [INN-Spanish]; [2-(4-butylsulfanyl-benzhydrylmercapto)-ethyl]-dimethyl-amine; 1-(4-Butylmercapto-benzhydrylmercapto)-2-dimethylamino-ethan; Covatix

物化性质

• 密度: 1.08g/cm3
• 沸点: 466.1ºC at 760mmHg
• 分子式: C₂₁H₂₉NS₂
• 分子量: 359.59200
• 闪点: 235.7ºC
• 精确质量: 359.17400
• PSA: 53.84000
• LogP: 5.96300
• 蒸汽压: 7.26E-09mmHg at 25°C
• 折射率: 1.596
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KQ8563000 CHEMICAL NAME : Ethylamine, 2-((p-(butylthio)-alpha-phenylbenzyl)thio)-N,N-dimeth yl- CAS REGISTRY NUMBER : 486-17-9 BEILSTEIN REFERENCE NO. : 2625367 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C21-H29-N-S2 MOLECULAR WEIGHT : 359.63 WISWESSER LINE NOTATION : 4SR DYR&S2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3800 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 343 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - body temperature decrease Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1630 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 116 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 108,201,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,440,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 72 mg/kg TOXIC EFFECTS : Behavioral - ataxia REFERENCE : CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 12,448,1963

合成路线

1126-80-3 ~% 486-17-9

文献：Takahashi,K. et al. Chemical and Pharmaceutical Bulletin, 1960 , vol. 8, p. 757 - 762

98-88-4 ~% 486-17-9

文献：Takahashi,K. et al. Chemical and Pharmaceutical Bulletin, 1960 , vol. 8, p. 757 - 762

73242-21-4 4584-46-7 ~% 486-17-9

文献：Takahashi,K. et al. Chemical and Pharmaceutical Bulletin, 1960 , vol. 8, p. 757 - 762

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