4438-22-6

• 常用中文名：氧化阿托品
• 常用英文名：Benzeneacetic acid, a-(hydroxymethyl)-,8-methyl-8-oxido-8-azabicyclo[3.2.1]oct-3-yl ester, endo
• CAS号：4438-22-6
• 分子式：C₁₇H₂₃NO₄
• 分子量：305.36900
• 发布时间：2016-03-12 14:02:11
• 更新时间：2026-07-17 10:36:42

名称

• 中文名: 氧化阿托品
• 英文名: 8-Azabicyclo[3.2.1]octan-3.α.-ol, 8-methyl-, 8-oxide, tropate
• 中文别名: 硫酸阿托品杂质H; 硫酸阿托品杂质13; 阿托品杂质22; 阿托品氧化物; 阿托品氮氧化物
• 英文别名: DL-Tropasaeure-(8-oxy-tropan-3endo-ylester); Atropine N-oxide; (1R,3r,5S)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane 8-oxide; atropine oxide; Atropine Sulfate Impurity H; NSC-72861; NSC72861; DL-tropic acid-(8-oxy-tropane-3endo-yl ester); Aminoxytropine tropate; Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-oxido-8-azabicyclo[3.2.1]oct-3-yl ester, endo; Atropine sulfate Impurity 13; Atropine Impurity 22; Atropine Impurity 32; Genatropine

物化性质

• 分子式: C₁₇H₂₃NO₄
• 分子量: 305.36900
• 精确质量: 305.16300
• PSA: 75.96000
• LogP: 1.90230

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YM6105000 CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+-)-tropate (ester), 8-oxide CAS REGISTRY NUMBER : 4438-22-6 LAST UPDATED : 198708 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C17-H23-N-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RDMU** "Vergleichende Untersuchungen uber Genatropin und Atropin, Dissertation," Rathscheck, U., Pharmakologischen Institut der Westfalichen Wilhelms-Universitat Muenster/Westf., Fed. Rep. Ger., 1934 Volume(issue)/page/year: -,-,1934 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,513,1948