27321-96-6

• 常用中文名：胆甾醇聚乙二醇
• 常用英文名：2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13- dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[ a]phenanthren-3-yl]oxy]ethanol
• CAS号：27321-96-6
• 分子式：C₂₉H₅₀O₂
• 分子量：430.70600
• 相关类别： 研究领域 其他
• 发布时间：2018-09-15 19:03:25
• 更新时间：2024-01-02 12:36:20
• Chol-PEG是一种非离子表面活性剂囊泡,可用于血液持久性药物输送系统[1][2]。

名称

• 中文名: 胆甾醇聚乙二醇
• 英文名: 2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13- dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[ a]phenanthren-3-yl]oxy]ethanol

物化性质

• 密度: 1g/cm3
• 沸点: 524.9ºC at 760mmHg
• 分子式: C₂₉H₅₀O₂
• 分子量: 430.70600
• 闪点: 210.5ºC
• 精确质量: 430.38100
• PSA: 29.46000
• LogP: 7.40530

生物活性

• 描述: Chol-PEG是一种非离子表面活性剂囊泡,可用于血液持久性药物输送系统[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Yang DB, et, al. Synthesis and application of poly(ethylene glycol)-cholesterol (Chol-PEGm) conjugates in physicochemical characterization of nonionic surfactant vesicles. Colloids Surf B Biointerfaces. 2008 Jun 1;63(2):192-9.

  [2]. Barnard A, et, al. Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures. Org Biomol Chem. 2012 Nov 14;10(42):8403-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MD0400000 CHEMICAL NAME : Glycols, polyethylene, monocholesteryl ether CAS REGISTRY NUMBER : 27321-96-6 LAST UPDATED : 199701 DATA ITEMS CITED : 6 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human - man REFERENCE : CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat REFERENCE : CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - guinea pig REFERENCE : CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9020 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 93 (estimated) No. of Female Employees: 56 (estimated)