611225-63-9

• 常用中文名：4-[4-(甲氨基)-3-硝基苯氧基]-2-吡啶羧酸-1,1-二甲基乙酯
• 常用英文名：2-Pyridinecarboxylic acid, 4-[4-(methylamino)-3-nitrophenoxy]-, 1,1-dimethylethyl ester
• CAS号：611225-63-9
• 分子式：C₁₇H₁₉N₃O₅
• 分子量：345.35000
• 发布时间：2018-12-28 10:53:02
• 更新时间：2024-01-09 13:43:35

名称

• 中文名: 4-[4-(甲氨基)-3-硝基苯氧基]-2-吡啶羧酸-1,1-二甲基乙酯
• 英文名: 2-Pyridinecarboxylic acid, 4-[4-(methylamino)-3-nitrophenoxy]-, 1,1-dimethylethyl ester
• 中文别名: 2-甲基-2-丙基4-[4-(甲基氨基)-3-硝基苯氧基]-2-吡啶羧酸酯
• 英文别名: tert-butyl 4-[4-(methylamino)-3-nitrophenoxy]pyridine-2-carboxylate; tert-butyl 4-(4-(methylamino)-3-nitrophenoxy)picolinate; 4-[(Aminomethyl)phenyl]piperazine,N1-BOC protected; TERT-BUTYL 4-[4-(AMINOMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE; 1-Boc-4-(4-Aminomethylphenyl)piperazine; 4-(4-aminomethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4-(aminomethyl)phenyl)piperazine-1-carboxylate; 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzylamine; 2-Methyl-2-propanyl 4-[4-(methylamino)-3-nitrophenoxy]-2-pyridinecarboxylate

物化性质

• 密度: 1.27g/cm3
• 沸点: 497.734°C at 760 mmHg
• 分子式: C₁₇H₁₉N₃O₅
• 分子量: 345.35000
• 闪点: 254.821°C
• 精确质量: 345.13200
• PSA: 106.27000
• LogP: 4.37530
• 折射率: 1.596

合成路线

77-78-1 ~73% 611225-63-9

文献：NOVARTIS AG Patent: WO2008/27523 A2, 2008 ; Location in patent: Page/Page column 26-27 ;

611225-60-6 77-78-1 ~76% 611225-63-9

文献：NOVARTIS AG Patent: WO2008/140850 A1, 2008 ; Location in patent: Page/Page column 56-57 ; WO 2008/140850 A1

611225-62-8 ~% 611225-63-9

文献：Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard Patent: US2004/122237 A1, 2004 ; Location in patent: Page 88-89 ; US 20040122237 A1

611225-60-6 74-88-4 ~46% 611225-63-9

文献：Ramurthy, Savithri; Subramanian, Sharadha; Aikawa, Mina; Amiri, Payman; Costales, Abran; Dove, Jeff; Fong, Susan; Jansen, Johanna M.; Levine, Barry; Ma, Sylvia; McBride, Christopher M.; Michaelian, Jonah; Pick, Teresa; Poon, Daniel J.; Girish, Sandhya; Shafer, Cynthia M.; Stuart, Darrin; Sung, Leonard; Renhowe, Paul A. Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7049 - 7052

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