61397-56-6

• 常用中文名：cis-苯甲酸-[2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲酯
• 常用英文名：CIS-2-(BROMOMETHYL)-2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLANE-4-YLMETHYL BENZOATE
• CAS号：61397-56-6
• 分子式：C₁₈H₁₅BrCl₂O₄
• 分子量：446.11900
• 发布时间：2018-02-04 08:00:00
• 更新时间：2026-08-14 22:58:36
• 【用途一】
  主要用于药物酮康唑和伊曲康唑的合成

名称

• 中文名: 顺式溴代酯
• 英文名: cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate
• 中文别名: 顺式溴代酯(伊曲); 顺式溴代酯CIS-2-[(BROMOMETHYL)2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLAN-4-YL METHYL]BENZOATE; 酮康唑杂质43; (2R,4R)-REL-2-(溴甲基)-2-(2,4-二氯苯基)-4-苯甲酸甲酯-1,3-二氧代环己烷; 顺式-苯甲酸-[2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲酯; 顺-苯甲酸-[2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲酯; 顺式溴代酯,CIS-苯甲酸-2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基甲酯; 顺-[2-(溴甲基)-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲醇苯甲酸酯; ((2R,4R)-2-(溴甲基)-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基)苯甲酸甲酯; 达泊西汀盐酸盐杂质 L; REL-((2R,4R)-2-(溴甲基)-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基)甲基苯甲酸酯; CIS-苯甲酸-[2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲酯(61-6); 伊曲康唑杂质38; 顺式-2-(溴甲基)-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲基苯甲酸酯; 顺-(2-溴甲基)-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基苯甲酸甲酯; 苯甲酸-[2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基]甲酯; 溴苯甲酸酯; 顺式溴代酯 (酮康唑); CIS-苯甲酸-2-溴甲基-2-(2,4-二氯苯基)-1,3-二氧戊环-4-基甲酯
• 英文别名: cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate; CIS-2-[2,4-DICHLOROPHENYL]-2-BROMOMETHYL-4-(BENZOYLOXY)METHYL-1,3-DIOXALANE; Cis Bromobenzoate (CBB); ((3S,5R)-5-(BROMOMETHYL)-5-(2,4-DICHLOROPHENYL)TETRAHYDROFURAN-3-YL)METHYL BENZOATE; Rel-((2R,4R)-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl benzoate; Cis-Bromobenzoate cis; cis-[2-Bromomethyl-2-(2,4-dichlorophenyl); 2-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]benzoic acid methyl ester; Cis-bromo-ester(Cis-BBD); CIS Bromo; cis-BroMo-ester [cis-2-(2; CIS-BBD; (Z)-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-ylmethyl benzoate; (2R,4R)-rel-2-(BroMoMethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-Methanol Benzoate; Cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]; Cis-2-(Bromomethyl)-2-(2,4-Dichlorophenyl)-1,3-Dioxolane-4-Ylmethyl Benzoate [CBB]; CIS -[2-BROMOMETHYL-2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLAN-4-YL]METHYL BENZOATE /CIS -BROMOBENZOATE; TIANFU CHEM--cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate; Ketoconazole Impurity 43; CIS-BROMO-ESTER [CIS-2-(2,4-DICHLOROPHENYL)-2-BROMOMETHYL-4-(BENZOYLOXY)-METHYL-1,3-DIOXALANE]; CIS-2-(BROMOMETHYL)-2-(2,4DICHLORO PHENYL)-1,3-DIOXOLANE-4-YLMETHYL BENZOATE(CIS BROMO BENZOATE); MFCD01073078; Cis bromo benzoate (int of ketoconazole and many other); CIS -BROMOBENZOATE:CIS -[2-BROMOMETHYL-2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLAN-4-YL]METHYL BENZOATE; Cis- 2-BroMoMethyl-2-(2,4-Dich; CIS-[2-BROMOMETHYL-2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLAN-4-YL]METHYL BENZOATE; 3-dioxalane]; EINECS 262-765-9; Cis-(2-(2,bromomethyl)-2-(-2,4- -Oichophenyl)-1,3-Dioxolan-4- yl}methyl benzoate; cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate(50 GMS); cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate ISO 9001：2015 REACH; ((2R,4R)-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl benzoate; CIS-BROMO BENZOATE; ((2R,4S)-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl benzoate; cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxola; CI2-2-(BROMOMETHYL)-2-(2,4 DICHLOROPHENYL)-1,3-DIOXOLAN E-4-YLMETHYL BENZOATE; Dapoxetine Impurity L; 1,3-Dioxolane-4-Methanol,2-(broMoMethyl)-2-(2,4-dichlorophenyl)-, 4-benzoate, (2R,4R)-rel; cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-methanolbenzoate; Cis-2-bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-methanolbenzoate; Cis Bromo Benzoate (cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate)-S; cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3- dioxolan-4-yl]methyl Benzoate(CBB); CisBromoBenzoateItraconazole; Dapoxetine hydrochloride Impurity L; [(2s,4s)-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate; cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate (10GMS); Itraconazole Impurity 38; 1,3-DIOXOLANE-4-METHANOL, 2-(BROMOMETHYL)-2-(2,4-DICHLOROPHENYL)-BENZOATE,(2R,4R)-REL; 4-Dichlorophenyl)-2-broMoMethyl-4-(benzoyloxy)-Methyl-1; CIS-BROMO-ESTER; Cis-[(2-Bromomethyl)-2(2,4-Dichlorophenyl)-1,3-Dioxolan-4-Yl] Methyl Benxoate

物化性质

• 密度: 1.512g/cm3
• 沸点: 517ºC at 760 mmHg
• 分子式: C₁₈H₁₅BrCl₂O₄
• 分子量: 446.11900
• 闪点: 266.5ºC
• 精确质量: 443.95300
• PSA: 44.76000
• LogP: 4.81350
• 折射率: 1.59
• 储存条件: 2-8°C

合成路线

68751-57-5 98-88-4 ~50% 61397-56-6 61397-56-6

文献：Baji; Kimny, Tan; Gasquez; Flammang; Compagnon; Delcourt; Mathieu; Viossat; Morgant; Nguyen-Huy European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 637 - 650

532-32-1 497250-93-8 ~53% 61397-56-6 61397-56-6

文献：Camps, Pelayo; Farres, Xavier; Garcia, Luisa; Ginesta, Joan; Pascual, Jaume; et al. Tetrahedron: Asymmetry, 1995 , vol. 6, # 6 p. 1283 - 1294

172032-21-2 ~% 61397-56-6

文献：European Journal of Medicinal Chemistry, , vol. 32, # 7-8 p. 637 - 650

2234-16-4 ~% 61397-56-6

文献：European Journal of Medicinal Chemistry, , vol. 32, # 7-8 p. 637 - 650

2631-72-3 ~% 61397-56-6

文献：Tetrahedron: Asymmetry, , vol. 6, # 6 p. 1283 - 1294

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