124012-42-6

• 常用中文名：加洛他滨
• 常用英文名：N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]-3,4,5-trimethoxybenzamide
• CAS号：124012-42-6
• 分子式：C₁₉H₂₂FN₃O₈
• 分子量：439.39200
• 发布时间：2018-05-07 08:00:00
• 更新时间：2026-07-24 13:43:25

名称

• 中文名: 加洛他滨
• 英文名: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]-3,4,5-trimethoxybenzamide
• 中文别名: 加西他滨
• 英文别名: Galocitabine; Cytidine,5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl); N-(3,4,5-Trimethoxybenzoyl)-5'-deoxy-5-fluorocytidine; Cytidine, 5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl); Galocitabina [INN-Spanish]; N-[1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydro-4-pyrimidinyl]-3,4,5-trimethoxybenzamide; Galocitabinum [INN-Latin]; 5'-deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine; Ro-09-1390; Ro 0; Neofrutulon; Galocytabine; galocitabine; 5'-Deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine; Galocitabine [INN]; 5'-Deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)cytidine; N4-Trimethoxybenzoyl-5'-deoxy-5-fluorocytidine

物化性质

• 分子式: C₁₉H₂₂FN₃O₈
• 分子量: 439.39200
• 精确质量: 439.13900
• PSA: 141.37000
• LogP: 0.37260

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HA3857500 CHEMICAL NAME : Cytidine, 5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)- CAS REGISTRY NUMBER : 124012-42-6 LAST UPDATED : 199703 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C19-H22-F-N3-O8 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6300 mg/kg/7D-I TOXIC EFFECTS : Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 21,29,1996

合成路线

161599-31-1 ~% 124012-42-6

文献：Bioorganic and Medicinal Chemistry, , vol. 8, # 7 p. 1697 - 1706

4521-61-3 ~% 124012-42-6

文献：Bioorganic and Medicinal Chemistry, , vol. 8, # 7 p. 1697 - 1706

1380532-03-5 ~% 124012-42-6

文献：Organic Letters, , vol. 14, # 13 p. 3348 - 3351

161599-46-8 ~% 124012-42-6

文献：Bioorganic and Medicinal Chemistry, , vol. 8, # 7 p. 1697 - 1706

27821-07-4 ~% 124012-42-6

文献：Bioorganic and Medicinal Chemistry, , vol. 8, # 7 p. 1697 - 1706

上下游产品

上游产品  3
4521-61-3 161599-46-8 27821-07-4
下游产品  4
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