494-03-1

• 常用中文名：萘氮芥
• 常用英文名：N,N-BIS(2-CHLOROETHYL)-2-NAPHTHYLAMINE
• CAS号：494-03-1
• 分子式：C₁₄H₁₅Cl₂N
• 分子量：268.18200
• 发布时间：2018-04-18 08:00:00
• 更新时间：2024-01-02 22:45:40

名称

• 中文名: 萘氮芥
• 英文名: N,N-bis(2-chloroethyl)naphthalen-2-amine
• 英文别名: Nafticlorina; Chlornaftina; Chloronaftina; Chlornaphthin; Aleukon; Chlornaphazine; Chloronaphthina; Cloronaftina; Chloronaphthine; Chlornaphazin

物化性质

• 密度: 1.234g/cm3
• 沸点: 414.3ºC at 760 mmHg
• 分子式: C₁₄H₁₅Cl₂N
• 分子量: 268.18200
• 闪点: 204.4ºC
• 精确质量: 267.05800
• PSA: 3.24000
• LogP: 4.12380
• 蒸汽压: 4.49E-07mmHg at 25°C
• 折射率: 1.63
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QM2450000 CHEMICAL NAME : 2-Naphthylamine, N,N-bis(2-chloroethyl)- CAS REGISTRY NUMBER : 494-03-1 BEILSTEIN REFERENCE NO. : 3316600 LAST UPDATED : 199612 DATA ITEMS CITED : 21 MOLECULAR FORMULA : C14-H15-Cl2-N MOLECULAR WEIGHT : 268.20 WISWESSER LINE NOTATION : L66J CN2G2G HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1086 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 2468 mg/kg/6Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 3132 mg/kg/10Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE/DURATION : 3200 mg/kg/11Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 330 mg/kg/4W TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 4090 mg/kg/7Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 3200 mg/kg/11Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors TYPE OF TEST : Specific locus test TYPE OF TEST : Sex chromosome loss and nondisjunction MUTATION DATA TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 120 ug/L REFERENCE : AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** REVIEWS *** IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,119,1974 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,119,1974 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,130,1987 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970

上下游产品

上游产品  0
下游产品  1
63110-97-4