1508-45-8

• 常用中文名：米托肼
• 常用英文名：Naphtho[2,3-d]-1,3-dioxole-6-carboxylicacid,5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-,2-ethylhydrazide, (5R,6R,7R,8R)
• CAS号：1508-45-8
• 分子式：C₂₄H₃₀N₂O₈
• 分子量：474.50400
• 相关类别： 原料药 抗肿瘤药 天然来源类抗肿瘤药
• 发布时间：2018-07-01 18:19:09
• 更新时间：2026-07-15 20:02:50

名称

• 中文名: 米托肼
• 英文名: mitopodozide
• 英文别名: NSC-72274; Podophyllinic acid 2-ethylhydrazide; mitopodozide //BP; SP-I 77; Propesid; Proresid; trans-2-Ethylhydrazide; Proreside; Naphtho[2,3-d]-1,3-dioxole-6-cboxylic acid, 5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, 2-ethylhydrazide, (5R,6R,7R,8R)

物化性质

• 密度: 1.301g/cm3
• 沸点: 619.6ºC at 760mmHg
• 分子式: C₂₄H₃₀N₂O₈
• 分子量: 474.50400
• 闪点: 328.5ºC
• 精确质量: 474.20000
• PSA: 127.74000
• LogP: 2.26720
• 蒸汽压: 3.26E-16mmHg at 25°C
• 折射率: 1.587

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TP8800000 CHEMICAL NAME : Podophyllic acid, 2-ethylhydrazide CAS REGISTRY NUMBER : 1508-45-8 LAST UPDATED : 199012 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C24-H30-N2-O8 MOLECULAR WEIGHT : 474.56 WISWESSER LINE NOTATION : T C566 DO FO EH&&TJ JQ K1Q LVMM2 MR CO1 DO1 EO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1467,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,363,1970