490-82-4

• 常用中文名：硫代硫胺素
• 常用英文名：Oxo Thiamine
• CAS号：490-82-4
• 分子式：C₁₂H₁₆N₄O₂S
• 分子量：280.34600
• 发布时间：2018-12-10 19:17:06
• 更新时间：2026-07-01 06:49:11

名称

• 中文名: 3-[(4-氨基-2-甲基嘧啶l)甲基]-5-(2-羟基乙基)-4-甲基噻唑-2(3h)-酮、
• 英文名: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2-one
• 中文别名: 3-[(4-氨基-2-甲基嘧啶L)甲基]-5-(2-羟基乙基)-4-甲基噻唑-2(3H)-酮; 维生素B1杂质D; 四水合辅酸酶杂质4; 3-[(4-氨基-2-甲基嘧啶-5-基)甲基]-5-(2-羟乙基)-4-甲基噻唑-2(3H)-酮; 硫胺素杂质4 (硫胺素杂质D); 硫胺素(维生素B1)杂质D; 含氧硫胺素; 硫胺素(维生素B1)杂质4(硫胺素(维生素B1)杂质D); 硝酸硫胺杂质D; 盐酸硫胺素杂质D; 硫胺杂质D; 盐酸硫胺杂质D; 维生素B1杂质4; 氧代硫胺素; 硫胺素杂质D; 硫胺素杂质D(氧代硫胺素); 羰基合成硫胺; 羰基硫胺
• 英文别名: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one; Vitamin B1 Impurity 4; Oxo ThiaMine; Conuclase tetrahydrate impurity 4; 3-[(4-Amino-2-Methyl-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolone; EINECS 207-719-0; Thiamine HCl Impurity D; Thiamine thiazolone; Thiamine Hydrochloride Impurity D; 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2(3H)-one (oxothiamine); 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one; 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-(3H)-thiazolone; 2(3h)-thiazolone,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl; 3-((4-amino-2-methylpyrimidin-5-yl)methyl); Thiamine Nitrate Impurity D; 3-(4-Amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-aethyl)-4-methyl-3H-thiazol-2-on; (3H)-Thiazolone,3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl; thiamine thiazolone; 2(3H)-Thiazolone, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl; Thiamine Impurity D(Oxo Thiamine); Thiamine Impurity D; 3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2-one; 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-one; thiamine thiazolin-2-one; 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazol-2-one; Tiamintiazolone [Italian]; Thiaminthiazolone; Thiamine Impurity 4（Thiamine Impurity D）

物化性质

• 密度: 1.378g/cm3
• 沸点: 507ºC at 760mmHg
• 分子式: C₁₂H₁₆N₄O₂S
• 分子量: 280.34600
• 闪点: 260.4ºC
• 精确质量: 280.09900
• PSA: 122.27000
• LogP: 1.06310
• 蒸汽压: 4.23E-11mmHg at 25°C
• 折射率: 1.662
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XJ7054240 CHEMICAL NAME : (3H)-Thiazolone, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydro xyethyl)-4-methyl- CAS REGISTRY NUMBER : 490-82-4 BEILSTEIN REFERENCE NO. : 0310984 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C12-H16-N4-O2-S MOLECULAR WEIGHT : 280.38 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 23,69,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 730 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 23,69,1968 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 23,69,1968

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