37927-01-8

• 常用中文名：(-)-地塞米松酸
• 常用英文名：(-)-Dexamethasone Acid
• CAS号：37927-01-8
• 分子式：C₂₁H₂₇FO₅
• 分子量：378.43400
• 发布时间：2017-03-05 06:23:25
• 更新时间：2026-06-30 11:10:12

名称

• 中文名: (-)-地塞米松酸
• 英文名: (-)-Dexamethasone Acid
• 中文别名: 塞米松磷酸钠杂质G; 地塞米松杂质2; 地塞米松磷酸钠杂质ZG; (8S,9R,10S,11S,13S,14S,16R,17R)-9-氟-11,17-二羟基-10,13,16-三甲基-3-氧亚基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊二烯并[A]菲-17-羧酸; 地塞米松酸; (8S,9R,10S,11S,13S,14S,16R,17R)-9-氟-11,17-二羟基-10,13,16-三甲基-3-氧代-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环庚烷并[a]菲-17-甲酸; 地塞米松磷酸钠杂质G; 地塞米松磷酸钠杂质7(地塞米松磷酸钠杂质G); 地塞米松杂质20; 地塞米松磷酸杂质ZG
• 英文别名: Dexamethasone-17β-cboxylic Acid; Dexamethasone acid; (–)-Dexamethasone acid; 9-fluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-cboxylic acid; Androsta-1,4-diene-17-cboxylic acid, 9-fluoro-11,17-dihydroxy-16-methyl-3-oxo-, (11β,16α,17α); Fluoroandrostadiene cboxylic acid; 9-Fluoro-11,17-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17-cboxylic Acid; Dexamethasone Sodium Phosphate Impurity 7; Dexamethasone Sodium Phosphate Impurity G (Dexamethasone Acid); Dexamethasone Sodium Phosphate Impurity 7(Dexamethasone Sodium Phosphate Impurity G); (11,16a,17a)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-cboxylic Acid; (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid; (11β,16α,17α)-9-Fluoro-11,17-dihydroxy-16-Methyl-3-oxo-androsta-1,4-diene-17-cboxylic Acid; DexaMethasone SodiuM phosphate IMpurity G ((-)-DexaMethasone Acid); Dexamethasone Impurity 2; (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-cboxylic acid; DexaMethasone SodiuM phosphate IMpurity G; 9-Fluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-cboxylic Acid; (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-cboxylic acid; 9-Fluoro-11β,17-dihydroxy-16α-Methyl-3-oxoandrosta -1,4-diene-17β-cboxylic Acid

物化性质

• 密度: 1.351g/cm3
• 沸点: 566.865ºC at 760 mmHg
• 熔点: 274-277ºC
• 分子式: C₂₁H₂₇FO₅
• 分子量: 378.43400
• 闪点: 296.63ºC
• 精确质量: 378.18400
• PSA: 94.83000
• LogP: 2.41890
• 折射率: 1.598
• 储存条件: 2-8°C

合成路线

50-02-2 ~99% 37927-01-8

文献：PFIZER LIMITED; GLOSSOP, Paul Alan; MILLAN, David Simon; PRICE, David Anthony Patent: WO2010/136940 A1, 2010 ; Location in patent: Page/Page column 64 ; WO 2010/136940 A1

2964-79-6 ~% 37927-01-8

文献：Edmonds, John S.; Morita, Masatoshi; Turner, Peter; Skelton, Brian W.; White, Allan H. Steroids, 2006 , vol. 71, # 1 p. 34 - 41

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