633-99-8

• 常用中文名：1-氯-2-萘酚
• 常用英文名：1-Chloro-2-naphthol
• CAS号：633-99-8
• 分子式：C₁₀H₇ClO
• 分子量：178.61500
• 发布时间：2018-07-25 22:14:36
• 更新时间：2024-01-02 11:42:24

名称

• 中文名: 1-氯-2-萘酚
• 英文名: 1-chloronaphthalen-2-ol
• 英文别名: chloro-2-naphthol; 1-chloro-2-naphthol; 2-Naphthalenol,1-chloro; 2-NAPHTHOL,1-CHLORO; 1-Chloro-2-Naphthalenol; 1-chloro-naphthalen-2-ol; 1-chloronaphthalene-2-ol; 1-chloro-2-naphtol; 1-Chloro-2-hydroxynaphthalene

物化性质

• 密度: 1.333g/cm3
• 沸点: 306.5ºC at 760 mmHg
• 熔点: 70ºC
• 分子式: C₁₀H₇ClO
• 分子量: 178.61500
• 闪点: 139.2ºC
• 精确质量: 178.01900
• PSA: 20.23000
• LogP: 3.19880
• 折射率: 1.684
• 储存条件: 室温，干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:1

  4.可旋转化学键数量:0

  5.互变异构体数量:3

  6.拓扑分子极性表面积:20.2

  7.重原子数量:12

  8.表面电荷:0

  9.复杂度:160

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QL3410000 CHEMICAL NAME : 2-Naphthol, 1-chloro- CAS REGISTRY NUMBER : 633-99-8 BEILSTEIN REFERENCE NO. : 1939233 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C10-H7-Cl-O MOLECULAR WEIGHT : 178.62 WISWESSER LINE NOTATION : L66J BG CQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2310 mg/kg TOXIC EFFECTS : Behavioral - withdrawal Gastrointestinal - changes in structure or function of salivary glands REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(4),55,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(4),55,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78. For publisher information, see IJSIDW. Volume(issue)/page/year: 30,89,1968

合成路线

上下游产品

上游产品  10
135-19-3 90-15-3 773-90-0 2283-08-1
64-17-5 708-06-5 17096-15-0 90-13-1
93-04-9 13101-92-3
下游产品  10
550-60-7 524-42-5 13101-92-3 13101-93-4
102169-88-0 135-19-3 6410-10-2 17096-15-0
2050-69-3 75907-52-7