74853-07-9

• 常用中文名：4-(4-(4-(4-甲氧基苯基)哌嗪-1-基)苯基)-1H-1,2,4-三唑-5(4H)-酮
• 常用英文名：4-(4-(4-(4-METHOXYPHENYL)PIPERAZIN-1-YL)PHENYL)-1H-1,2,4-TRIAZOL-5(4H)-ONE
• CAS号：74853-07-9
• 分子式：C₁₉H₂₁N₅O₂
• 分子量：351.402
• 发布时间：2018-03-29 08:00:00
• 更新时间：2026-07-21 18:45:55

名称

• 中文名: 泊沙康唑-5
• 英文名: 4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-1H-1,2,4-triazol-5-one
• 中文别名: 4-(4-(4-(4-甲氧基苯基)哌嗪-1-基)苯基)-2,4-二氢-3H-1,2,4-三唑-3-酮; 伊曲康唑甲氧基TRIAZOLONE杂质; 依曲康唑杂质 标准品; 泊沙康唑中间体-5; 2,4-二氢-4-[4-[4-(4-甲氧基苯基)哌嗪-1-基]苯基]-3H-1,2,4-三唑-3-酮; 4-(4-(4-(4-甲氧基苯基)哌嗪-1-基)苯基)-4H-1,2,4-三唑-3-醇
• 英文别名: 4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-1H-1,2,4-triazol-5-one; 2,4-Dihydro-4-[4-[4-(4-methoxypheny; Posaconazole Methoxy Triazole Impurity; 4-{4-[4-(4-methoxyphenyl)-piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one,2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]; 2,4-DIHYDRO-4-[4-[4-(4-METHOXYPHENYL)PIPERAZIN-1-YL]PHENYL]-3H-1,2,4-TRIAZOL-3-ONE(WXC08779); 4-{4-[4-(4-Methoxyphenyl)-1-piperazinyl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 2,4-Dihydro-4-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}-3H-1,2,4-triazol-3-one; 4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one; 4-[4-[4-(4-Methoxyphenyl)piperazino]phenyl]-3,4-dihydro-2H-1,2,4-triazole-3-one; 4-{4-[4-(4-Methoxyphenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazole-3- one; 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one; Posazonazole Intermediate 5; 4-(4-(4-(4-Methoxyphenyl)piperazin-1-yl)phenyl)-4H-1,2,4-triazol-3-ol; Posaconazole inter-5

物化性质

• 密度: 1.3±0.1 g/cm3
• 熔点: 270-277ºC (dec.)
• 分子式: C₁₉H₂₁N₅O₂
• 分子量: 351.402
• 精确质量: 351.169525
• PSA: 66.39000
• LogP: 1.01
• 折射率: 1.665
• 储存条件: 室温， 密封， 干燥， 惰性气体

安全

• 海关编码: 2933990090

合成路线

74852-89-4 143-37-3 ~28% 74853-07-9

文献：JANSSEN PHARMACEUTICA N.V. Patent: WO2006/67139 A1, 2006 ; Location in patent: Page/Page column 34 ; WO 2006/067139 A1

38212-30-5 ~% 74853-07-9

文献：Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900

100-00-5 ~% 74853-07-9

文献：Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900

74852-61-2 ~% 74853-07-9

文献：Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900

6313-33-3 74852-89-4 ~28% 74853-07-9

文献：Heeres; Backx; Van Cutsem Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900

74852-62-3 ~% 74853-07-9

文献：Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900

74853-06-8 ~% 74853-07-9

文献：Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900

上下游产品

上游产品  8
74852-89-4 143-37-3 38212-30-5 100-00-5
74852-61-2 6313-33-3 74852-62-3 74853-06-8
下游产品  3
89848-21-5 79538-90-2 153896-47-0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%