25231-21-4

• 常用中文名：聚-1,2-丙二醇十八烷基醚
• 常用英文名：ARLAMOL(TM) E
• CAS号：25231-21-4
• 分子式：(C₃H₆O)nC₁₈H₃₈O
• 分子量：328.57300
• 相关类别： 研究领域 其他
• 发布时间：2018-07-18 19:04:07
• 更新时间：2024-01-02 23:21:28
• 聚氧丙烯硬脂醚可用作赋形剂,如表面活性剂、柔软剂、润滑、润湿、增塑、增溶和分散性能。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

名称

• 中文名: 聚-1,2-丙二醇十八烷基醚
• 英文名: 1-octadecoxypropan-2-ol
• 英文别名: Poly(oxypropylene)stearyl ether; PPG-15 Stearyl ether; Polyoxypropylene (11) stearyl ether; PPG-11 Stearyl ether; Polyoxypropylene 15 stearyl ether; Stearyl alcohol,propoxylated; Prostearyl 15

物化性质

• 密度: 0.865g/cm3
• 沸点: 423.2ºC at 760mmHg
• 分子式: (C₃H₆O)nC₁₈H₃₈O
• 分子量: 328.57300
• 闪点: 157.1ºC
• 精确质量: 328.33400
• PSA: 29.46000
• LogP: 6.64530
• 蒸汽压: 6.19E-09mmHg at 25°C
• 折射率: 1.453

生物活性

• 描述: 聚氧丙烯硬脂醚可用作赋形剂,如表面活性剂、柔软剂、润滑、润湿、增塑、增溶和分散性能。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

MSDS

Section 1. Chemical Product and Company Identification Arlamol E Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Chemical Family Arlamol E Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsCLOSED CUP: Higher than 93.3°C (200°F). (Setaflash. ) Flammable LimitsNot available. Products of CombustionNot available. Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat. Various SubstancesNon-flammable in presence of shocks. Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillAbsorb with an inert material and put the spilled material in an appropriate waste disposal. Large SpillAbsorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Arlamol E Section 8. Exposure Controls/Personal Protection Engineering ControlsProvide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal ProtectionSafety glasses. Synthetic apron. Gloves (impervious). Respiratory protection is not necessary for normal handling. Good room ventilation or use of local exhaust (fume hood) is sufficient. Use a vapor respirator under conditions where exposure to the substance is apparent (e.g. generation of high concentrations of mist or vapor, inadequate ventilation, development of respiratory tract irritation), and engineering controls are not feasible. Be sure to use an approved/certified respirator or equivalent. Personal Protection in Case of Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a a Large Spillspecialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Liquid.OdorNot available. TasteNot available. Molecular WeightNot available. Colorless to light yellow. Color pH (1% soln/water)Not applicable. Boiling Point>100°C (212°F) <0°C (32°F) Melting Point Critical TemperatureNot available. 0.95 (Water = 1) Specific Gravity Vapor PressureNot available. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. Dispersion PropertiesIs not dispersed in cold water, hot water. SolubilityInsoluble in cold water, hot water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, incompatible materials Incompatibility with variousReactive with oxidizing agents. substances CorrosivityNot available. Not available. Special Remarks on Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Arlamol E Section 11. Toxicological Information Routes of EntryAbsorbed through skin. Eye contact. Inhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 10000 mg/kg [Rat]. Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified 4 (No evidence.) by NTP, None. by OSHA, None. by NIOSH. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherPotential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Short contact periods with human skin are not usually associated with skin irritaiton. Repeated or prolonged contact can result in slight skin irritation. Systemically toxic concentrations will probably not be absorbed through human skin. Eyes: No eye irritation is likelg to develop following contact with human eyes. Inhalation: No irritation is expected to be associated with inhalation of this material. No toxic effects are known to be associated with inhalation of this material. This material is considered to be essentially non-irritating to possibly slightly irritating upon ingestion. No toxic effects are expected following ingestion of this product. The toxicological properties of this substance have not been fully investigated. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Possibly hazardous short term degradation products are not likely. However, long term degradation products Products of Biodegradation may arise. Not available. Toxicity of the Products of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste must be disposed of in accordance with federal, state and local environmental Waste Disposal control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Special Provisions forNot applicable. Transport DOT (Pictograms) Arlamol E Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Arlamol E Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Listed on Canadian Domestic Substance List (DSL). China: Listed on National Inventory. Japan: Listed on National Inventory (ENCS). Korea: Listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)This product is not classifiedNot applicable. according to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection a WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Not applicable. Lab coat. Not applicable. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A