180691-65-0

• 常用中文名：3-(((三氟甲基)磺酰基)氧基)-5,6-二氢吡啶-1(2H)-羧酸叔丁酯
• 常用英文名：tert-butyl 5-(trifluoromethylsulfonyloxy)-3,6-dihydro-2H-pyridine-1-carboxylate
• CAS号：180691-65-0
• 分子式：C₁₁H₁₆F₃NO₅S
• 分子量：331.30900
• 发布时间：2018-12-31 20:36:32
• 更新时间：2024-01-12 10:28:02

名称

• 中文名: 3-(((三氟甲基)磺酰基)氧基)-5,6-二氢吡啶-1(2H)-羧酸叔丁酯
• 英文名: tert-butyl 5-(trifluoromethylsulfonyloxy)-3,6-dihydro-2H-pyridine-1-carboxylate
• 英文别名: 1-t-butoxycarbonyl-1,2,3,6-tetrahydro-5-trifluoromethanesulfonyloxypyridine; 5-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

物化性质

• 分子式: C₁₁H₁₆F₃NO₅S
• 分子量: 331.30900
• 精确质量: 331.07000
• PSA: 81.29000
• LogP: 3.39600

安全

• 海关编码: 2933399090

合成路线

37595-74-7 98977-36-7 ~39% 149108-74-7 180691-65-0

文献：AMGEN INC.; ALLEN, Jennifer; HORNE, Daniel B.; HU, Essa; KALLER, Matthew R.; MONENSCHEIN, Holger; NGUYEN, Thomas T.; REICHELT, Andreas; RZASA, Robert M. Patent: WO2011/143495 A1, 2011 ; Location in patent: Page/Page column 84 ; WO 2011/143495 A1

37595-74-7 98977-36-7 ~48% 180691-65-0

文献：Huestis, Malcolm P.; Liu, Wendy; Volgraf, Matthew; Purkey, Hans E.; Yu, Christine; Wang, Weiru; Smith, Darin; Vigers, Guy; Dutcher, Darrin; Hunt, Kevin W.; Siu, Michael Tetrahedron Letters, 2013 , vol. 54, # 43 p. 5802 - 5807

37595-74-7 ~30% 180691-65-0

文献：Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; Meegalla, Sanath K.; Rudolph, M. Jonathan; Wall, Mark J.; Wilson, Kenneth J.; Desjarlais, Renee L.; Manthey, Carl L.; Molloy, Christopher J. Patent: US2008/51402 A1, 2008 ; Location in patent: Page/Page column 59-60 ; US 20080051402 A1

98977-36-7 ~30% 180691-65-0

文献：Baumann, Christian Andrew; Gaul, Michael David; Johnson, Dana L.; Tuman, Robert W. Patent: US2006/281788 A1, 2006 ; Location in patent: Page/Page column 73 ; US 20060281788 A1

145100-51-2 98977-36-7 ~% 180691-65-0

文献：JANSSEN RandD IRELAND; GUILLEMONT, Jerôme Emile Georges; LANÇOIS, David Francis Alain; MOTTE, Magali Madeleine Simone; BALEMANS, Wendy Mia Albert; KOUL, Anil Patent: WO2014/23815 A1, 2014 ; Location in patent: Page/Page column 42; 43 ;

98977-36-7 ~10% 149108-74-7 180691-65-0

文献：F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; JUNG, Laurence Patent: US2013/102601 A1, 2013 ; Location in patent: Paragraph 0183 ;

37595-74-7 98977-36-7 ~% 456-64-4 180691-65-0

文献：OSI PHARMACEUTICALS, INC.; CHEN, Xin; JIN, Meizhong; KLEINBERG, Andrew; LI, An-hu; MULVIHILL, Mark, J.; STEINIG, Arno, G.; WANG, Jing Patent: WO2010/59771 A1, 2010 ; Location in patent: Page/Page column 47 ;

82113-65-3 98977-36-7 ~% 149108-74-7 180691-65-0

文献：Vicart; Cazes; Gore Tetrahedron Letters, 1995 , vol. 36, # 28 p. 5015 - 5018

上下游产品

上游产品  4
37595-74-7 98977-36-7 145100-51-2 82113-65-3
下游产品  1
885693-20-9

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%