1206524-85-7

• 常用中文名：(33R,35S,91R,92R,5S)-5-(叔丁基)-17-甲氧基-4,7-二氧基-2,8-二氧基-6-氮杂-1(2,3)-喹恶啉-3(3,1)-吡咯烷-9(1,2)-环丙烷环己基-35-羧酸
• 常用英文名：MK-5172
• CAS号：1206524-85-7
• 分子式：C₂₉H₃₈N₄O₇
• 分子量：554.635
• 发布时间：2016-05-23 00:11:28
• 更新时间：2026-07-19 11:34:16
• MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.

名称

• 中文名: (33R,35S,91R,92R,5S)-5-(叔丁基)-17-甲氧基-4,7-二氧基-2,8-二氧基-6-氮杂-1(2,3)-喹恶啉-3(3,1)-吡咯烷-9(1,2)-环丙烷环己基-35-羧酸
• 英文名: (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
• 中文别名: MK-5172中间体倒数第二步中间体; MK-5172倒数第二步中间体; 13C,2H3]- 格拉瑞韦; 格佐普韦杂质2; 格佐匹韦中间体5; MK-5172中间体N-2; (1,5S,8S,10R,22-5-(1,1-二甲基乙基)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A- 十四氢-14-甲氧基-3,6-二氧代-8H-7,10-亚甲基环丙烷并[18,19] [1,10,3,6]二氧杂二环草壬基十八碳-7-烯[11,12-B]喹喔啉-8-羧酸; (3R,3S,9R,9R,5S)-5-(叔丁基)-1-甲氧基-4,7-二氧代-2,8-二氧杂-6-氮杂-1(2,3)-喹喔啉-3(3,1)-吡咯烷-9(1,2)-环丙烷环十四烷-3-羧酸
• 英文别名: (1,5S,8R,10S,22-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-cboxylic acid; (1,5S,8S,10R,22-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-cboxylic acid; azoprevir Intermediate 5; (1,5S,8S,10R,22-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-cboxylic acid; Grazoprevir; MK-5172 intermidiate; S1492_Selleck; 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-cboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-,(1,5S,8S,10R,22); EOS-61017; (1R,18R,20R,24S,27S)-7-Methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0.0.0]nonacosa-3,5,7,9,11-pentaene-27-carboxylic acid; azoprevir Impurity 2; (33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-cboxylicacid; (1R,18R,20S,24S,27S)-7-Methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0.0.0]nonacosa-3,5(10),6,8,11-pentaene-27-carboxylic acid; UNII-RU4QU6O6X6

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 825.0±65.0 °C at 760 mmHg
• 分子式: C₂₉H₃₈N₄O₇
• 分子量: 554.635
• 闪点: 452.7±34.3 °C
• 精确质量: 554.274048
• PSA: 143.67000
• LogP: 4.64
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.616
• 储存条件: -20°C，干燥密封

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