N-[3-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-B]pyridazin-6-Yl}oxy)phenyl]-1,3-Dimethyl-1h-Pyrazole-5-Carboxamide

• 常用名: N-[3-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-B]pyridazin-6-Yl}oxy)phenyl]-1,3-Dimethyl-1h-Pyrazole-5-Carboxamide
• 英文名: N-[3-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-B]pyridazin-6-Yl}oxy)phenyl]-1,3-Dimethyl-1h-Pyrazole-5-Carboxamide
• CAS号: 1005780-85-7
• 分子量: 431.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁N₇O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[3-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-B]pyridazin-6-Yl}oxy)phenyl]-1,3-Dimethyl-1h-Pyrazole-5-Carboxamide

物理化学性质

• 分子式: C₂₂H₂₁N₇O₃
• 分子量: 431.4
• InChIKey: IFFBOVLYGJAFKB-UHFFFAOYSA-N
• SMILES: Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1

靶点实验

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实验名称：Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3094551

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Inhibition of c-Met (unknown origin) using biotinylated poly-GluTyr (4:1) as substrat... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL3094553

实验名称：Inhibition of human VEGFR2 using biotinylated poly-GluTyr as substrate by AlphaScreen... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL2410842

实验名称：Antiproliferative activity against VEGF-treated HUVEC after 5 days by WST-8 assay 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL2410841

实验名称：Kinetic solubility of the compound in 2nd fluid of Disintegration Test of the Japanes... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2410840

实验名称：Inhibition of VEGFR1 (unknown origin) using biotinylated poly-GluTyr as substrate by ... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 1 External Id：CHEMBL2410839

实验名称：Inhibition of p38alpha (unknown origin) 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL2410834

实验名称：Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP 来源：ChEMBL 靶标：Serine/threonine-protein kinase B-raf External Id：CHEMBL2410833

实验名称：Metabolic stability in mouse liver microsomes 来源：ChEMBL 靶标：Liver External Id：CHEMBL2410832

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