双酚-alpha-2,2’,6,6’-D4

• 常用名: 双酚-alpha-2,2’,6,6’-D4
• 英文名: 4,4'-Propane-2,2-diyldi(2,6-2H2)phenol
• CAS号: 102438-62-0
• 分子量: 232.311
• 密度: 1.1±0.1 g/cm3
• 沸点: 400.8±25.0 °C at 760 mmHg
• 分子式: C₁₅H₁₂D₄O₂
• 熔点: N/A
• 闪点: 192.4±17.8 °C

双酚-alpha-2,2’,6,6’-D4用途

双酚A-d4是氘标记的双酚A[1]。双酚A是一种酚类有机合成化合物,广泛用于生产聚碳酸酯塑料和环氧树脂。双酚A是一种生殖、发育和全身毒性物质,通常被归类为内分泌干扰物(EDC)。双酚A与许多疾病有关,包括心血管疾病、呼吸系统疾病、糖尿病、肾脏疾病、肥胖和生殖障碍[2][3]。

双酚-alpha-2,2’,6,6’-D4名称

• 中文名: 双酚-alpha-2,2’,6,6’-D4
• 英文名: bisphenol-a-2,2',6,6'-d4

双酚-alpha-2,2’,6,6’-D4生物活性

• 描述: 双酚A-d4是氘标记的双酚A[1]。双酚A是一种酚类有机合成化合物,广泛用于生产聚碳酸酯塑料和环氧树脂。双酚A是一种生殖、发育和全身毒性物质,通常被归类为内分泌干扰物(EDC)。双酚A与许多疾病有关,包括心血管疾病、呼吸系统疾病、糖尿病、肾脏疾病、肥胖和生殖障碍[2][3]。
• 相关类别:
  研究领域 >> 内分泌
• 体外研究: 氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

  [2]. Huang M, et al. Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells. Chemosphere. 2020 Apr 9;253:126707.

  [3]. Rubin BS, et al. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):27-34.

双酚-alpha-2,2’,6,6’-D4物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 400.8±25.0 °C at 760 mmHg
• 分子式: C₁₅H₁₂D₄O₂
• 分子量: 232.311
• 闪点: 192.4±17.8 °C
• 精确质量: 232.140137
• PSA: 40.46000
• LogP: 3.43
• InChIKey: IISBACLAFKSPIT-LNFUJOGGSA-N
• SMILES: CC(C)(c1ccc(O)cc1)c1ccc(O)cc1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.599

双酚-alpha-2,2’,6,6’-D4靶点实验

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双酚-alpha-2,2’,6,6’-D4英文别名

• 4,4'-(2,2-Propanediyl)di(2,6-H)phenol
• 4,4'-Propane-2,2-diyldi(2,6-H)phenol