N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide

• 常用名: N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide
• 英文名: N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide
• CAS号: 1025010-91-6
• 分子量: 535.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₇F₂N₇O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide

物理化学性质

• 分子式: C₂₇H₂₇F₂N₇O₃
• 分子量: 535.5
• InChIKey: YQQFRBUHZZNTGY-UHFFFAOYSA-N
• SMILES: NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1

靶点实验

查看更多实验

实验名称：Metabolic stability in mouse liver microsomes 来源：ChEMBL 靶标：Liver External Id：CHEMBL928639

实验名称：Metabolic stability per 10^6 cells in mouse hepatocytes 来源：ChEMBL 靶标：N/A External Id：CHEMBL928640

实验名称：Clearance in mouse at 20 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL928641

实验名称：Bioavailability in mouse at 20 mg/kg, ip 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL928642

实验名称：Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL928636

实验名称：AUC(0 to 8 hrs) in mouse at 50 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL928643

实验名称：Inhibition of human c-MET 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL1826790

实验名称：Permeability across human Caco-2 cells 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL928645

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