(2R)-N-(1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetamide

• 常用名: (2R)-N-(1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetamide
• 英文名: (2R)-N-(1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetamide
• CAS号: 1026086-99-6
• 分子量: 444.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₀F₂N₄O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (2R)-N-(1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetamide

物理化学性质

• 分子式: C₂₄H₃₀F₂N₄O₂
• 分子量: 444.5
• InChIKey: HQRSMNLSFMUJPL-KOSHJBKYSA-N
• SMILES: C1CC(C[C@@H]1[C@@](C2=CC=CC=C2)(C(=O)NC3CCN(CC3)CC4=NC(=CC=C4)N)O)(F)F

靶点实验

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实验名称：Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2 External Id：CHEMBL748253

实验名称：In vitro metabolic stability in dog hepatic microsomes (1 mg protein/mL), expressed a... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL823963

实验名称：Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M1 expressed... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL744762

实验名称：In vitro metabolic stability in human hepatic microsomes (1 mg protein/mL), expressed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL824125

实验名称：Selectivity ratio for binding affinity towards M2 muscarinic receptor to that of M3 m... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptors; M2 & M3 External Id：CHEMBL747621

实验名称：Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CH... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL744769

实验名称：Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M3 expressed... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M3 External Id：CHEMBL747663

实验名称：In vitro metabolic stability determined after 30 min of incubation in human hepatic m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL620140

实验名称：Selectivity ratio between m2 muscarinic and m3 muscarinic receptors 来源：ChEMBL 靶标：Muscarinic acetylcholine receptors; M2 & M3 External Id：CHEMBL841227

实验名称：Metacholine provocation test was conducted 4 hr after oral administration (1 mg/kg) i... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL822011

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