(R)-N-(7-(4-((4'-Chlorobiphenyl-2-Yl)methyl)piperazin-1-Yl)quinazolin-4-Yl)-4-(4-(Dimethylamino)-1-(Phenylthio)butan-2-Ylamino)-3-Nitrobenzenesulfonamide

• 常用名: (R)-N-(7-(4-((4'-Chlorobiphenyl-2-Yl)methyl)piperazin-1-Yl)quinazolin-4-Yl)-4-(4-(Dimethylamino)-1-(Phenylthio)butan-2-Ylamino)-3-Nitrobenzenesulfonamide
• 英文名: (R)-N-(7-(4-((4'-Chlorobiphenyl-2-Yl)methyl)piperazin-1-Yl)quinazolin-4-Yl)-4-(4-(Dimethylamino)-1-(Phenylthio)butan-2-Ylamino)-3-Nitrobenzenesulfonamide
• CAS号: 1027344-89-3
• 分子量: 837.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₃H₄₅ClN₈O₄S₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (R)-N-(7-(4-((4'-Chlorobiphenyl-2-Yl)methyl)piperazin-1-Yl)quinazolin-4-Yl)-4-(4-(Dimethylamino)-1-(Phenylthio)butan-2-Ylamino)-3-Nitrobenzenesulfonamide

物理化学性质

• 分子式: C₄₃H₄₅ClN₈O₄S₂
• 分子量: 837.5
• InChIKey: LLJSSTLCMHGPSB-UUWRZZSWSA-N
• SMILES: CN(C)CCC(CSc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ncnc3cc(N4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc23)cc1[N+](=O)[O-]

靶点实验

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实验名称：Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitiv... 来源：ChEMBL 靶标：Bcl-2-like protein 1 External Id：CHEMBL1693053

实验名称：Binding affinity to Bcl-Xl assessed as association rate constant by surface plasmon r... 来源：ChEMBL 靶标：Bcl-2-like protein 1 External Id：CHEMBL1693054

实验名称：Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay 来源：ChEMBL 靶标：Apoptosis regulator Bcl-2 External Id：CHEMBL1693055

实验名称：Displacement of wild type mBimBH3 from human Bcl-w by solution competition assay 来源：ChEMBL 靶标：Bcl-2-like protein 2 External Id：CHEMBL1693159

实验名称：Displacement of wild type mBimBH3 from Mcl-1 by solution competition assay 来源：ChEMBL 靶标：Induced myeloid leukemia cell differentiation protein Mcl-1 External Id：CHEMBL1693338

实验名称：Cytotoxicity against mouse MEF cells expressing mcl-1 fl/fl after 24 hrs by Cell tite... 来源：ChEMBL 靶标：MEF External Id：CHEMBL1693331

实验名称：Cytotoxicity against mouse mcl-1 deficient MEF cells after 24 hrs by Cell titer glo a... 来源：ChEMBL 靶标：MEF External Id：CHEMBL1693332

实验名称：Cytotoxicity against mouse MEF cells expressing mcl-1 fl/fl after 24 hrs by Cell tite... 来源：ChEMBL 靶标：MEF External Id：CHEMBL1693333

实验名称：Cytotoxicity against mouse mcl-1 deficient MEF cells after 24 hrs by Cell titer glo a... 来源：ChEMBL 靶标：MEF External Id：CHEMBL1693334

实验名称：Cytotoxicity against human NCI-H146 after 48 hrs by MTS assay in presence of 10% huma... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1693335

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