苏沃雷生

• 常用名: 苏沃雷生
• 英文名: Suvorexant(MK-4305)
• CAS号: 1030377-33-3
• 分子量: 450.921
• 密度: 1.4±0.1 g/cm3
• 沸点: 669.8±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₃ClN₆O₂
• 熔点: 153℃
• 闪点: 358.9±34.3 °C

苏沃雷生用途

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.

苏沃雷生名称

• 中文名: 5-氯-2-[(5R)-5-甲基-4-[5-甲基-2-(2H-1,2,3-三唑-2-基)苯甲酰基]-1,4-二氮杂环庚烷-1-基]-1,3-苯并恶唑
• 英文名: suvorexant
• 中文别名: 萨沃瑞斯特 | 苏沃雷生

苏沃雷生物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 669.8±65.0 °C at 760 mmHg
• 熔点: 153℃
• 分子式: C₂₃H₂₃ClN₆O₂
• 分子量: 450.921
• 闪点: 358.9±34.3 °C
• 精确质量: 450.157104
• PSA: 80.29000
• LogP: 3.62
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.703
• 储存条件: 室温，干燥，密封

苏沃雷生安全信息

• 危害码 (欧洲): Xi

苏沃雷生英文别名

• Belsomra
• [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
• [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
• [(R)-4-(5-chlorobenzoxazol-2-yl)-7-methyl-[1,4]diazepan-1-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)methanone
• Methanone, [(7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]-
• [(R)-4-(5-chlorobenzooxazol-2-yl)-7-methyl-[1,4]diazepan-1-yl](5-methyl-2-[1,2,3]triazol-2-yl-phenyl)methanone
• Suvorexant
• 5-chloro-2-{(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}-1,3-benzoxazole
• DORA-analogue
• [(7R)-4-(5-chlorobenzoxazol-2-yl)-7-methylhexahydro-1H-1,4-diazepin-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
• MK-4305