5-(6-(3-(Methylsulfonyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

• 常用名: 5-(6-(3-(Methylsulfonyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
• 英文名: 5-(6-(3-(Methylsulfonyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
• CAS号: 1033736-15-0
• 分子量: 468.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₀N₆O₃S₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5-(6-(3-(Methylsulfonyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

物理化学性质

• 分子式: C₂₁H₂₀N₆O₃S₂
• 分子量: 468.6
• InChIKey: GBHDCSZQCFDEEU-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)c1cccc(-c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)c1

靶点实验

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实验名称：Plasma protein binding in rat at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1109714

实验名称：Oral bioavailability in rat at 5 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1109713

实验名称：Hepatic clearance in rat liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1109711

实验名称：Thermodynamic solubility at pH 6.5 来源：ChEMBL 靶标：N/A External Id：CHEMBL1109710

实验名称：Antiproliferative activity against human MCF7.1 cells after 3 days by celltiter-glo l... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1109709

实验名称：Clearance in rat at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1109708

实验名称：Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylati... 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL1109707

实验名称：Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulat... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL1109706

实验名称：Unbound clearance in rat at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1109715

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