BM-131246

• 常用名: BM-131246
• 英文名: BM-131246
• CAS号: 103787-97-9
• 分子量: 408.47000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀N₂O₄S
• 熔点: N/A
• 闪点: N/A

BM-131246用途

BM-131246 是一种可口服的抗糖尿病剂。

BM-131246名称

• 中文名: BM-131246
• 英文名: 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

BM-131246生物活性

• 描述: BM-131246 是一种可口服的抗糖尿病剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体内研究: BM-131246被迅速吸收并且在ob/ob小鼠中达到血浆水平的大致成比例增加。在重复口服剂量后,BM-131246的终末半衰期约为4小时[1]。
• 参考文献:

  [1]. Heitzmann T, et al. Dose proportionality studies of novel thiazolidinedione derivatives as potent antidiabetic agents in mice. Arzneimittelforschung. 1995 Dec;45(12):1284-8.

BM-131246物理化学性质

• 分子式: C₂₂H₂₀N₂O₄S
• 分子量: 408.47000
• 精确质量: 408.11400
• PSA: 106.73000
• LogP: 4.49440
• InChIKey: GUTCYOKMCPFRGH-UHFFFAOYSA-N
• SMILES: Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC2SC(=O)NC2=O)cc1
• 储存条件: 2-8℃

BM-131246靶点实验

查看更多实验

实验名称：Antihyperglycemic activity was determined by measuring percent decrease in plasma glu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL714391

实验名称：Binding affinity at human PPAR gamma 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL824656

实验名称：Antihyperglycemic activity was determined by measuring percent decrease in plasma glu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL714393

实验名称：Binding affinity towards human peroxidase proliferator activated receptor alpha (hPPA... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL824654

实验名称：Transcriptional activation in CV-1 cells expressing hPPARalpha 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL824653

实验名称：Human Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-a... 来源：IUPHAR-DB 靶标：Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-activated receptors) [Homo sapiens] External Id：595_Human

实验名称：Effective dose to reduce 25% of glucose levels in blood 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL735674

实验名称：Binding affinity at human peroxidase proliferator activated receptor gamma (hPPARgamm... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL824659

实验名称：Activation of peroxisome proliferator activated receptor gamma measured by induction ... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL758987

实验名称：Transcriptional activation in CV- cells expressing hPPARgamma 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL824658

共19条，当前第1页，共2页

1

2

BM-131246英文别名

• 5-[4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxyl]benzyl]thiazolidine-2,4-dione
• 5-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-thiazolidine-2,4-dione
• AD-7057
• 5-(4-(2-(5-methyl-2-phenyloxazol-4-yl)-ethoxy)-benzyl)-thiazolidine-2,4-dione
• BM-131246