9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤

• 常用名: 9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤
• 英文名: 2'-Deoxy-2'-fluoroguanosine
• CAS号: 103884-98-6
• 分子量: 285.23
• 密度: 2.2±0.1 g/cm3
• 沸点: 726.1ºC
• 分子式: C₁₀H₁₂FN₅O₄
• 熔点: N/A
• 闪点: 392.9ºC

9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤用途

2-氨基-9-((2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)-3,9-二氢-6H-嘌呤-6-酮(9-β-D-[2'-氟-2'-脱氧阿拉伯呋喃基]-鸟嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤名称

• 中文名: 9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤
• 英文名: 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤生物活性

• 描述: 2-氨基-9-((2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)-3,9-二氢-6H-嘌呤-6-酮(9-β-D-[2'-氟-2'-脱氧阿拉伯呋喃基]-鸟嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤物理化学性质

• 密度: 2.2±0.1 g/cm3
• 沸点: 726.1ºC
• 分子式: C₁₀H₁₂FN₅O₄
• 分子量: 285.23
• 闪点: 392.9ºC
• 精确质量: 285.087341
• PSA: 139.28000
• LogP: -0.53
• InChIKey: UXUZARPLRQRNNX-UHFFFAOYSA-N
• SMILES: Nc1nc2c(ncn2C2OC(CO)C(O)C2F)c(=O)[nH]1
• 蒸汽压: 3.94E-22mmHg at 25°C
• 折射率: 1.876
• 储存条件: 2-8℃，避光

9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤毒性和生态

9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤靶点实验

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实验名称：Compound was tested for its ability to inhibit the incorporation of [3H]dThd into DNA... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL701050

实验名称：Cytotoxicity was evaluated by measuring the inhibition of HSV replication in vero cel... 来源：ChEMBL 靶标：Vero External Id：CHEMBL820065

实验名称：Concentration required to inhibit HSV-1 strain KOS cytopathic effect by 50% was measu... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL694043

实验名称：Inhibition of DNA synthesis in L1210 cells by the compound was determined the reduced... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL704582

实验名称：Inhibition of DNA synthesis in L1210 cells by the compound was determined the reduced... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL704581

实验名称：Inhibition of protein synthesis in L1210 cells by the compound was determined the red... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL704583

实验名称：Inhibition of RNA synthesis in L1210 cells by the compound was determined the reduced... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL873013

实验名称：Concentration required to inhibit HSV-2 strain 186 cytopathic effect by 50% was measu... 来源：ChEMBL 靶标：Human alphaherpesvirus 2 External Id：CHEMBL689430

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9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤英文别名

• 2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one
• 2'-Deoxy-2'-fluoroguanosine