6-[4-(Dimethylamino)-1-piperidinyl]-4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-3-cinnolinecarboxamide

• 常用名: 6-[4-(Dimethylamino)-1-piperidinyl]-4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-3-cinnolinecarboxamide
• 英文名: 6-[4-(Dimethylamino)-1-piperidinyl]-4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-3-cinnolinecarboxamide
• CAS号: 1041852-86-1
• 分子量: 452.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₉FN₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-[4-(Dimethylamino)-1-piperidinyl]-4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-3-cinnolinecarboxamide

物理化学性质

• 分子式: C₂₄H₂₉FN₆O₂
• 分子量: 452.5
• InChIKey: FTFHWXBKWLAUKB-UHFFFAOYSA-N
• SMILES: COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1N1CCC(N(C)C)CC1

靶点实验

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实验名称：Volume of distribution at steady state in rat at 10 mg/kg, po and 3 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2411825

实验名称：Half life in rat at 10 mg/kg, po and 3 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2411824

实验名称：Solubility of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL2411829

实验名称：Fraction unbound in rat plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL2411828

实验名称：Clearance in rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2411827

实验名称：Oral bioavailability in rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2411826

实验名称：Inhibition of human ERG 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL2411831

实验名称：Inhibition of human Nav1.5 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL2411830

实验名称：Antiproliferative activity against CSF-1-stimulated mouse 3T3 cells expressing CSF1R 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL2411836

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