N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3, 4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-ca rboxamide

• 常用名: N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3, 4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-ca rboxamide
• 英文名: N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3, 4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-ca rboxamide
• CAS号: 1044586-68-6
• 分子量: 541.85600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₃Cl₃N₄O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3, 4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-ca rboxamide

物理化学性质

• 分子式: C₂₇H₂₃Cl₃N₄O₂
• 分子量: 541.85600
• 精确质量: 540.08900
• PSA: 79.90000
• LogP: 7.83040
• InChIKey: IDUFEEHNNASCMH-UHFFFAOYSA-N
• SMILES: Cc1cc(C(=O)NC2CC(C)(C)Oc3nc(-c4ccc(Cl)cc4Cl)c(-c4ccc(Cl)cc4)cc32)n[nH]1

靶点实验

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实验名称：Volume of distribution at steady state in Beagle dog at 0.2 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1110969

实验名称：Plasma clearance in Beagle dog at 0.2 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1110968

实验名称：Dose normalized AUC in Sprague-Dawley rat assessed as per mg of plasma protein at 2 m... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1110966

实验名称：Bioavailability in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1110965

实验名称：Half life in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1110964

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1110963

实验名称：Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1110962

实验名称：Oral bioavailability in rhesus monkey at 0.4 mg/kg 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL1110977

实验名称：Half life in rhesus monkey at 0.4 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL1110975

实验名称：Volume of distribution at steady state in rhesus monkey at 0.4 mg/kg, po 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL1110974

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