1-(4-(4-(4-(2,6-Dip-tolylisonicotinoyl)piperazin-1-yl)piperidine-1-carbonyl)piperidin-1-yl)ethanone

• 常用名: 1-(4-(4-(4-(2,6-Dip-tolylisonicotinoyl)piperazin-1-yl)piperidine-1-carbonyl)piperidin-1-yl)ethanone
• 英文名: 1-(4-(4-(4-(2,6-Dip-tolylisonicotinoyl)piperazin-1-yl)piperidine-1-carbonyl)piperidin-1-yl)ethanone
• CAS号: 1045331-27-8
• 分子量: 607.8
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₇H₄₅N₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-(4-(4-(4-(2,6-Dip-tolylisonicotinoyl)piperazin-1-yl)piperidine-1-carbonyl)piperidin-1-yl)ethanone

物理化学性质

• 分子式: C₃₇H₄₅N₅O₃
• 分子量: 607.8
• InChIKey: YZIRPGUREXXEJC-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCC(C(=O)N2CCC(N3CCN(C(=O)c4cc(-c5ccc(C)cc5)nc(-c5ccc(C)cc5)c4)CC3)CC2)CC1

靶点实验

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实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, po administered as single dose 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1685970

实验名称：AUC in Sprague-Dawley rat at 10 mg/kg, po administered as single dose 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1685971

实验名称：Inhibition of fatty acid synthesis in human HepG2 cells assessed as [14C]acetate inco... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL1685974

实验名称：Inhibition of human ACC1/2 assessed as [14C]malonyl-CoA synthesis 来源：ChEMBL 靶标：Acetyl-CoA carboxylase 2 External Id：CHEMBL1685975

实验名称：AUC in Sprague-Dawley rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1113131

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1113130

实验名称：Metabolic stability in rat liver microsome assessed as drug remaining at 5 uM after 1... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1110307

实验名称：Metabolic stability in human liver microsome assessed as drug remaining at 5 uM after... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1110306

实验名称：Inhibition of fatty acid synthesis in human HepG2 cells after 48 hrs 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL1110303

实验名称：Induction of fatty acid oxidation in human HepG2 cells after 48 hrs 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL1110302

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