3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)-N-[2-(dimethylamino)ethyl]benzamide

• 常用名: 3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)-N-[2-(dimethylamino)ethyl]benzamide
• 英文名: 3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)-N-[2-(dimethylamino)ethyl]benzamide
• CAS号: 1056225-17-2
• 分子量: 458.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₆N₆O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)-N-[2-(dimethylamino)ethyl]benzamide

物理化学性质

• 分子式: C₂₅H₂₆N₆O₃
• 分子量: 458.5
• InChIKey: NCMNSDQGHJLYTB-BKUYFWCQSA-N
• SMILES: CN(C)CCNC(=O)c1cccc(-c2c[nH]c(C=C3C(=O)Nc4ccc(NC(N)=O)cc43)c2)c1

靶点实验

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实验名称：Growth inhibition of human MDA468 cells in tissue culture plastic at <10 uM 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL889498

实验名称：Inhibition of AKT2 来源：ChEMBL 靶标：RAC-beta serine/threonine-protein kinase External Id：CHEMBL889499

实验名称：Inhibition of AKT phosphorylation in PC3 cells 来源：ChEMBL 靶标：3-phosphoinositide-dependent protein kinase 1 External Id：CHEMBL889500

实验名称：Solubility in PBS 来源：ChEMBL 靶标：N/A External Id：CHEMBL889505

实验名称：Thermodynamic aqueous solubility of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL5121331

实验名称：Half life in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL889501

实验名称：PDK1-mediated AKT2 Activation Assay (cAKT2 33P-SPA) from Article 10.1016/j.bmcl.2007.... 来源：BindingDB 靶标：N/A External Id：BindingDB_2109_1

实验名称：Clearance in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL889502

实验名称：Volume of distribution at steady state in rat 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL889503

实验名称：Stability in human liver microsomes after 1 hr 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL889504

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