2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)

• 常用名: 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)
• 英文名: 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)
• CAS号: 1058170-45-8
• 分子量: 406.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₃FN₄S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)

物理化学性质

• 分子式: C₂₃H₂₃FN₄S
• 分子量: 406.5
• InChIKey: WDEKUGNKKOGFOA-UHFFFAOYSA-N
• SMILES: CCC1=CC(=C(C=C1C)C)NC2=NC(=CS2)C3=CC(=C(C=C3)N4C=C(N=C4)C)F

靶点实验

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实验名称：Half life in po dosed mouse 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155479

实验名称：Oral bioavailability in po dosed mouse 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155480

实验名称：Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as effect o... 来源：ChEMBL 靶标：Gamma-secretase subunit APH-1B External Id：CHEMBL5030177

实验名称：Reduction in amyloid beta 42 levels in Tg 2576 mouse brain at 50 to 100 mg/kg adminis... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4431693

实验名称：Drug level in C57/BL/6 mouse brain at 50 mg/kg, po dosed once daily 来源：ChEMBL 靶标：Brain External Id：CHEMBL2155485

实验名称：Ratio of drug level in brain to plasma in C57/BL/6 mouse at 50 mg/kg, po dosed once d... 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL2155486

实验名称：Plasma concentration in C57/BL/6 mouse at 50 mg/kg, po dosed once daily 来源：ChEMBL 靶标：Plasma External Id：CHEMBL2155484

实验名称：Antialzheimer activity in Tg2576 mouse assessed as reduction in plaque load in brain ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155489

实验名称：Antialzheimer activity in Tg2576 mouse assessed as reduction in plaque load in brain ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155488

实验名称：Tmax in po dosed mouse 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2155477

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