2-[3-oxo-3-[4-(thiophene-2-carbonyl)piperazin-1-yl]propyl]-3H-quinazolin-4-one

• 常用名: 2-[3-oxo-3-[4-(thiophene-2-carbonyl)piperazin-1-yl]propyl]-3H-quinazolin-4-one
• 英文名: 2-[3-oxo-3-[4-(thiophene-2-carbonyl)piperazin-1-yl]propyl]-3H-quinazolin-4-one
• CAS号: 1060969-56-3
• 分子量: 396.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀N₄O₃S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-[3-oxo-3-[4-(thiophene-2-carbonyl)piperazin-1-yl]propyl]-3H-quinazolin-4-one

物理化学性质

• 分子式: C₂₀H₂₀N₄O₃S
• 分子量: 396.5
• InChIKey: YMIQFFBYZDVYBQ-UHFFFAOYSA-N
• SMILES: O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(C(=O)c2cccs2)CC1

靶点实验

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实验名称：Half life in human hepatocytes 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3107733

实验名称：Metabolic stability in human plasma assessed as compound recovery after 2 hrs 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3107734

实验名称：Ratio of drug level in blood to plasma (unknown origin) after 60 mins 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL3107735

实验名称：Activity at P-gp (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL3107871

实验名称：Efflux ratio of permeability in human Caco2 cells 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL3107872

实验名称：Growth inhibition of human MDA-MB-436 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3107873

实验名称：Inhibition of PARP-1-mediated PARylation in H2O2-induced human HeLa cells preincubate... 来源：ChEMBL 靶标：Poly [ADP-ribose] polymerase 1 External Id：CHEMBL3107874

实验名称：Inhibition of GST-tagged recombinant human PARP-1 expressed in Escherichia coli after... 来源：ChEMBL 靶标：Poly [ADP-ribose] polymerase 1 External Id：CHEMBL3107875

实验名称：Toxicity in SCID beige mouse xenografted with human MX1 cells assessed as body weight... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3107876

实验名称：Toxicity in SCID beige mouse xenografted with human MX1 cells assessed as lethality a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3107877

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