SMND-309

• 常用名: SMND-309
• 英文名: SMND-309
• CAS号: 1065559-56-9
• 分子量: 358.29900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₄O₈
• 熔点: N/A
• 闪点: N/A

SMND-309用途

SMND-309是丹酚酸B衍生物,对体内外的鼠皮质神经元损伤有保护作用。

SMND-309名称

• 中文名: SMND-309
• 英文名: (E)-2-[6-[(E)-2-carboxyethenyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

SMND-309生物活性

• 描述: SMND-309是丹酚酸B衍生物,对体内外的鼠皮质神经元损伤有保护作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hou J, Tian J, Jiang W, Gao Y, Fu F. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Eur J Pharmacol. 2011 Jan 10;650(1):390-5.

  [2]. Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J. Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23.

  [3]. Tian J, Fu F, Li G, Wang Y, Gao Y, Liu Z, Zhang S. SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: characterization and role. Brain Res. 2009 Mar 31;1263:114-21.

  [4]. Tian J, Li G, Zhang S, Gao Y, Jiang W, Fu F, Liu Z. SMND-309, a novel derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons. Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):176-84.

  [5]. Jian Hou et al. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis European Journal of Pharmacology Volume 650, Issue 1, 10 January 2011, Pages 390-395

SMND-309物理化学性质

• 分子式: C₁₈H₁₄O₈
• 分子量: 358.29900
• 精确质量: 358.06900
• PSA: 155.52000
• LogP: 2.23200
• InChIKey: OAHRXWZJURTMHG-OEKSYNDNSA-N
• SMILES: O=C(O)C=Cc1ccc(O)c(O)c1C(=Cc1ccc(O)c(O)c1)C(=O)O
• 储存条件: 2-8℃

SMND-309英文别名

• SMND-309||SMND309
• CS-0559
• SMND309
• salvianolic acid E
• SMND-309