D-threo-PDMP

• 常用名: D-threo-PDMP
• 英文名: D-threo-PDMP
• CAS号: 109836-82-0
• 分子量: 427.02000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₉ClN₂O₃
• 熔点: N/A
• 闪点: N/A

D-threo-PDMP用途

D-threo-PDMP是一种有效的糖神经酰胺合酶(GCS)抑制剂,它通过抑制糖基化减少细胞表面的鞘糖脂,减少轴突丛的总长度和轴突分支点的数量,并抑制轴突生长[1][2]。

D-threo-PDMP名称

• 英文名: d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hcl

D-threo-PDMP生物活性

• 描述: D-threo-PDMP是一种有效的糖神经酰胺合酶(GCS)抑制剂,它通过抑制糖基化减少细胞表面的鞘糖脂,减少轴突丛的总长度和轴突分支点的数量,并抑制轴突生长[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
• 体外研究: D-苏氨酸PDMP预处理肝细胞可消除 TNF-α(280 ng/mL)对糖磷脂水平的刺激并增强神经酰胺的产生[1]。 D-苏氨酸PDMP(20μM,48小时)明显刺激系膜肾小球系膜细胞(GMC)的增殖,这些增殖被外源神经节苷脂混合物(0.1-0.2 mg/mL)或 GM3(20-100μM)以剂量依赖的方式明显减弱。它还诱发了神经节苷脂表达的明显减少[2]。
• 参考文献:

  [1]. Carmen García-Ruiz, et al. Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest. 2003 Jan;111(2):197-208.

  [2]. Dong Hoon Kwak, et al. Ganglioside GM3 inhibits the high glucose- and TGF-beta1-induced proliferation of rat glomerular mesangial cells. Life Sci. 2005 Sep 30;77(20):2540-51.

D-threo-PDMP物理化学性质

• 分子式: C₂₃H₃₉ClN₂O₃
• 分子量: 427.02000
• 精确质量: 426.26500
• PSA: 61.80000
• LogP: 4.80850
• InChIKey: UYNCFCUHRNOSCN-FYYLOGMGSA-N
• SMILES: CCCCCCCCCC(=O)NC(CN1CCOCC1)C(O)c1ccccc1

D-threo-PDMP靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Inhibitory effect on outgrowth of MRRL-CH1 cell line at 1 uM concentration; No Effect 来源：ChEMBL 靶标：MRRL-CH1 External Id：CHEMBL714458

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3... 来源：NCGC External Id：epac1-inhibitor-v

实验名称：Inhibitory effect on outgrowth of MRRL-CH1 cell line at 5 uM concentration; No Effect 来源：ChEMBL 靶标：MRRL-CH1 External Id：CHEMBL714460

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E... 来源：NCGC External Id：epac2-activator-v2

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4... 来源：NCGC External Id：epac2-inhibitor-v2

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

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