AMG7703

• 常用名: AMG7703
• 英文名: AMG7703
• CAS号: 1103523-24-5
• 分子量: 294.800
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₄H₁₅ClN₂OS
• 熔点: N/A
• 闪点: N/A

AMG7703用途

AMG7703(4-CMTB,AMG-7703)是FFAR2(GPR43)的变构选择性激动剂。

AMG7703名称

• 英文名: AMG7703

AMG7703生物活性

• 描述: AMG7703(4-CMTB,AMG-7703)是FFAR2(GPR43)的变构选择性激动剂。
• 参考文献: References 1. Hansen AH, et al. J Med Chem. 2018 Sep 24. doi: 10.1021/acs.jmedchem.8b00855. 2. Swaminath G, et al. FEBS Lett. 2010 Oct 8;584(19):4208-14. View Related Products by Target Free Fatty Acid Receptor (FFAR)

AMG7703物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₄H₁₅ClN₂OS
• 分子量: 294.800
• 精确质量: 294.059357
• LogP: 4.36
• InChIKey: AZYDQCGCBQYFSE-LBPRGKRZSA-N
• SMILES: CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1
• 折射率: 1.620

AMG7703靶点实验

查看更多实验

实验名称：Fraction unbound in mouse plasma at 5 uM after 4 hrs by equilibrium dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158283

实验名称：Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158156

实验名称：Unbound clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4158284

实验名称：Half life in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/M... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4158285

实验名称：Oral bioavailability in Sprague-Dawley rat at 3 mg/kg administered via gavage as sing... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4158286

实验名称：Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTP... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158279

实验名称：Octanol-PBS buffer partition coefficient, log D of the compound at pH 7.4 by shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158281

实验名称：Fraction unbound in rat plasma at 5 uM after 4 hrs by equilibrium dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158282

实验名称：Antidiabetic activity in C57Bl/6J mouse assessed as inhibition of blood glucose AUC (... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4158291

实验名称：Dose normalized unbound AUC in Sprague-Dawley rat at 3 mg/kg, po administered via gav... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4158287

共32条，当前第1页，共4页

1

2

3

4

AMG7703英文别名

• AMG7703
• (2S)-2-(4-Chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide
• MFCD21603909