N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

• 常用名: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide
• 英文名: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide
• CAS号: 1107014-69-6
• 分子量: 445.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₇N₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

物理化学性质

• 分子式: C₂₅H₂₇N₅O₃
• 分子量: 445.5
• InChIKey: OJLASFAHNJPVLA-UHFFFAOYSA-N
• SMILES: Cc1ccccc1C(=O)C1CCN(c2ccc(C(=O)NCC(O)c3cccnc3)nn2)CC1

靶点实验

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实验名称：Reduction of plasma triglyceride level in Zucker fatty rat at 30 mg/kg, po qd for 7 d... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1071266

实验名称：Reduction of plasma triglyceride level in po dosed Zucker fatty rat administered qd f... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1071267

实验名称：Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate ... 来源：ChEMBL 靶标：Acyl-CoA desaturase 1 External Id：CHEMBL1071884

实验名称：AUC (0 to 8 hrs) in C57BL/6 mouse at 20 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071264

实验名称：Oral bioavailability in C57BL/6 mouse at 20 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071265

实验名称：Half life in C57BL/6 mouse at 20 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071263

实验名称：Inhibition of Scd1 in po dosed db/db mouse assessed as [14C]oleate to [14C]stearate r... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071891

实验名称：Half life in C57BL/6 mouse at 5 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071892

实验名称：Toxicity in Zucker fatty rat assessed as induction of narrow eye fissure at 30 mg/kg,... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1071272

实验名称：Metabolic stability in mouse liver S9 fraction assessed as compound remaining after 3... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1071890

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