N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-2-(2-fluoroethylamino)-4-(4-methylpiperazin-1-yl)benzamide

• 常用名: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-2-(2-fluoroethylamino)-4-(4-methylpiperazin-1-yl)benzamide
• 英文名: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-2-(2-fluoroethylamino)-4-(4-methylpiperazin-1-yl)benzamide
• CAS号: 1108743-71-0
• 分子量: 522.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₉F₃N₆O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-2-(2-fluoroethylamino)-4-(4-methylpiperazin-1-yl)benzamide

物理化学性质

• 分子式: C₂₈H₂₉F₃N₆O
• 分子量: 522.6
• InChIKey: HXYIPFOMCPLBAX-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NCCF

靶点实验

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实验名称：Inhibition of IR (unknown origin) in presence of gamma33-ATP 来源：ChEMBL 靶标：Insulin receptor External Id：CHEMBL3807418

实验名称：Intrinsic clearance in human liver microsomes at 1 mM preincubated for 5 mins followe... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3806984

实验名称：Apparent permeability from basolateral to apical side in human Caco2 cells at 2.5 mg/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3806983

实验名称：Apparent permeability from apical to basolateral side in human Caco2 cells at 2.5 mg/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3806919

实验名称：Clearance in Harlan nu/nu mouse at 10 mg/kg, iv administered as single dose by LC-MS/... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3806988

实验名称：AUC (infinity) in Harlan nu/nu mouse at 10 mg/kg, iv administered as single dose by L... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3806987

实验名称：Intrinsic clearance in rat hepatocytes at 1 mM after 10 to 90 mins by LC-MS/MS analys... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3806985

实验名称：Tmax in Harlan nu/nu mouse at 10 mg/kg, po administered as single dose by LC-MS/MS an... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3806992

实验名称：Half life in Harlan nu/nu mouse at 10 mg/kg, iv administered as single dose by LC-MS/... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3806990

实验名称：Volume of distribution at steady state in Harlan nu/nu mouse at 10 mg/kg, iv administ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3806989

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