雷公藤次碱

• 常用名: 雷公藤次碱
• 英文名: Wilforine
• CAS号: 11088-09-8
• 分子量: 867.845
• 密度: 1.4±0.1 g/cm3
• 沸点: 871.5±65.0 °C at 760 mmHg
• 分子式: C₄₃H₄₉NO₁₈
• 熔点: 158-163ºC
• 闪点: 480.9±34.3 °C

雷公藤次碱用途

雷公藤次碱 (Wilforine)是一倍半萜吡啶化合物,肺纤维化治疗的有效天然化合物。

雷公藤次碱名称

• 中文名: 雷公藤次碱
• 英文名: Wilforine

雷公藤次碱生物活性

• 描述: 雷公藤次碱 (Wilforine)是一倍半萜吡啶化合物,肺纤维化治疗的有效天然化合物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 其他
• 参考文献:

  [1]. Zhu C, et al. Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine. J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34.

  [2]. Miao GP, et al. Elicitation and in situ adsorption enhanced secondary metabolites production of Tripterygium wilfordii Hook. f. adventitious root fragment liquid cultures in shake flask and a modified bubble column bioreactor. Bioprocess Biosyst Eng. 2014

雷公藤次碱物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 871.5±65.0 °C at 760 mmHg
• 熔点: 158-163ºC
• 分子式: C₄₃H₄₉NO₁₈
• 分子量: 867.845
• 闪点: 480.9±34.3 °C
• 精确质量: 867.294983
• PSA: 252.75000
• LogP: 6.24
• InChIKey: ZOCKGJZEUVPPPI-NCHBRQRASA-N
• SMILES: CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(=O)c1ccccc1)C2OC(C)=O)C4(C)O
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.589
• 储存条件: 2-8℃

雷公藤次碱靶点实验

查看更多实验

实验名称：Inhibition of CYP2D6 in human liver microsomes assessed as reduction in formation of ... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL4178618

实验名称：Inhibition of CYP2E1 in human liver microsomes assessed as reduction in formation of ... 来源：ChEMBL 靶标：Cytochrome P450 2E1 External Id：CHEMBL4178619

实验名称：Cytotoxicity against human A2780 cells assessed as cell viability measured after 48 h... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL5608929

实验名称：Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL1... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL945493

实验名称：Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated TNF... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL945492

实验名称：Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL2... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL945495

实验名称：Immunosuppressive activity in human PBMC assessed as inhibition of LPS-stimulated IL8... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL945494

实验名称：Inhibition of CYP3A4 in human liver microsomes assessed as reduction in formation of ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4178614

实验名称：Inhibition of CYP1A2 in human liver microsomes assessed as reduction in formation of ... 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL4178615

实验名称：Inhibition of CYP2C9 in human liver microsomes assessed as reduction in formation of ... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL4178616

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雷公藤次碱英文别名

• (1S,3R,15S,18S,19R,20R,21R,22S,23R,24R,25R,26S)-20,22,23,25-Tetraacetoxy-21-(acetoxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.0.0.0]hexaco sa-7,9,11-trien-19-yl benzoate
• 20,22,23,25-Tetraacetoxy-21-(acetoxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.0.0.0]hexacosa-7,9,11-trien-19-yl benzoate
• 26-Deoxywilfordine