5-[[5-(1-methylpyrazol-4-yl)-4-[[(2S)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile

• 常用名: 5-[[5-(1-methylpyrazol-4-yl)-4-[[(2S)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile
• 英文名: 5-[[5-(1-methylpyrazol-4-yl)-4-[[(2S)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile
• CAS号: 1137478-45-5
• 分子量: 391.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₁N₉O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5-[[5-(1-methylpyrazol-4-yl)-4-[[(2S)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile

物理化学性质

• 分子式: C₁₉H₂₁N₉O
• 分子量: 391.4
• InChIKey: HGYKCQUYMKJVQI-HNNXBMFYSA-N
• SMILES: Cn1cc(-c2cnc(Nc3cnc(C#N)cn3)cc2NCC2CNCCO2)cn1

靶点实验

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实验名称：Selectivity index, ratio of GI50 for cytotoxicity against human SW620 cells to GI50 f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706940

实验名称：Displacement of [3H]astemizole from human ERG expressed in HEK293 cells at 10 uM by r... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4706924

实验名称： Determination of Inhibitor Potency Vs. CHK1 in Caliper Assay Format from US Patent U... 来源：BindingDB 靶标：N/A External Id：BindingDB_11559_1

实验名称：Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4706921

实验名称：Caliper Assay from US Patent US9663503: "5-[[4-[[morpholin-2-yl]methylamino]-5-(trifl... 来源：BindingDB 靶标：N/A External Id：BindingDB_1514_1

实验名称：Selectivity ratio of GI50 for antiproliferative activity against human HT-29 cells as... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706920

实验名称：Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4706923

实验名称：Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligan... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4706939

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