5-[[5-(3-hydroxy-3-methylbut-1-ynyl)-4-[[(2R)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile

• 常用名: 5-[[5-(3-hydroxy-3-methylbut-1-ynyl)-4-[[(2R)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile
• 英文名: 5-[[5-(3-hydroxy-3-methylbut-1-ynyl)-4-[[(2R)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile
• CAS号: 1137478-52-4
• 分子量: 393.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₃N₇O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5-[[5-(3-hydroxy-3-methylbut-1-ynyl)-4-[[(2R)-morpholin-2-yl]methylamino]pyridin-2-yl]amino]pyrazine-2-carbonitrile

物理化学性质

• 分子式: C₂₀H₂₃N₇O₂
• 分子量: 393.4
• InChIKey: IDZXROKRAQBADP-MRXNPFEDSA-N
• SMILES: CC(C)(O)C#Cc1cnc(Nc2cnc(C#N)cn2)cc1NCC1CNCCO1

靶点实验

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实验名称：Displacement of [3H]astemizole from human ERG expressed in HEK293 cells at 10 uM by r... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4706924

实验名称： Determination of Inhibitor Potency Vs. CHK1 in Caliper Assay Format from US Patent U... 来源：BindingDB 靶标：N/A External Id：BindingDB_11559_1

实验名称：Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4706921

实验名称：Caliper Assay from US Patent US9663503: "5-[[4-[[morpholin-2-yl]methylamino]-5-(trifl... 来源：BindingDB 靶标：N/A External Id：BindingDB_1514_1

实验名称：Selectivity ratio of GI50 for antiproliferative activity against human HT-29 cells as... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706920

实验名称：Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4706923

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