1-Methyl-2-(2-{[5-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethoxy)phenyl]amino}pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One

• 常用名: 1-Methyl-2-(2-{[5-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethoxy)phenyl]amino}pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One
• 英文名: 1-Methyl-2-(2-{[5-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethoxy)phenyl]amino}pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One
• CAS号: 1137825-76-3
• 分子量: 501.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₆F₃N₇O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-Methyl-2-(2-{[5-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethoxy)phenyl]amino}pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One

物理化学性质

• 分子式: C₂₄H₂₆F₃N₇O₂
• 分子量: 501.5
• InChIKey: CYXABCVHENZAID-UHFFFAOYSA-N
• SMILES: CN1CCN(c2ccc(OC(F)(F)F)c(Nc3nccc(-c4cc5c(n4C)CCNC5=O)n3)c2)CC1

靶点实验

查看更多实验

实验名称：Half life in Nu/Nu Balb Harlan mouse at 10 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1936752

实验名称：AUC (0 to infinity) in Nu/Nu Balb Harlan mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1936754

实验名称：Apparent permeability of the compound by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL1936745

实验名称：Apparent permeability across human Caco2 cells 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL1936744

实验名称：Intrinsic clearance in human liver microsomes at 1 uM 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1936747

实验名称：AUC (0 to infinity) in Nu/Nu Balb Harlan mouse at 10 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1936749

实验名称：Volume of distribution at steady state in Nu/Nu Balb Harlan mouse at 10 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1936751

实验名称：Clearance in Nu/Nu Balb Harlan mouse at 10 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1936750

实验名称：Cell cycle arrest in human A2780 cells assessed as accumulation at G2/M phase at 0.05... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL1936737

实验名称：Cell cycle arrest in human A2780 cells assessed as induction of phospho Thr199 nucleo... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL1936739

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