LUF5771

• 常用名: LUF5771
• 英文名: LUF5771
• CAS号: 1141802-49-4
• 分子量: 357.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₃NO₂
• 熔点: N/A
• 闪点: N/A

LUF5771用途

LUF5771是一种有效的变构重组促黄体生成激素(recLH)和Org 43553抑制剂。LUF5771能够以低效部分激活LH受体[1]。

LUF5771名称

• 中文名: 5-Phenyl-(1,1'-biphenyl)-3-yl N-cyclopentylcarbamate
• 英文名: LUF5771

LUF5771生物活性

• 描述: LUF5771是一种有效的变构重组促黄体生成激素(recLH)和Org 43553抑制剂。LUF5771能够以低效部分激活LH受体[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 其他
• 靶点实验:

  recLH and Org 43553[1]

• 体外研究: LUF5771(1µM或10µM)变构抑制是浓度依赖性的。LUF5771显著增加放射性配体离解。LUF5771可能与Org 43553一样与七个跨膜结构域结合。LUF5771(10µM)单独能够部分激活LH受体31±4%[1]。
• 参考文献:

  [1]. Laura H. Heitman, et al. Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor. Journal of Medicinal Chemistry 2009 52 (7), 2036-2042

LUF5771物理化学性质

• 分子式: C₂₄H₂₃NO₂
• 分子量: 357.44
• InChIKey: YNYOWRRXJIPCGX-UHFFFAOYSA-N
• SMILES: O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

LUF5771靶点实验

查看更多实验

实验名称：Antagonist activity at human luteinizing hormone receptor expressed in CHOK1 cells as... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018024

实验名称：Antagonist activity at human luteinizing hormone receptor expressed in CHOK1 cells as... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018025

实验名称：Displacement of [125I]human chorionic gonadotropin from human luteinizing hormone rec... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018022

实验名称：Antagonist activity at human luteinizing hormone receptor expressed in CHOK1 cells as... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018023

实验名称：Displacement of [125I]human chorionic gonadotropin from human luteinizing hormone rec... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018021

实验名称：Displacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHO... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018018

实验名称：Displacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHO... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018019

实验名称：Activity at adenosine A3 receptor assessed as allosteric modulation 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL1018028

实验名称：Agonist activity at human luteinizing hormone receptor expressed in CHOK1 cells asses... 来源：ChEMBL 靶标：Lutropin-choriogonadotropic hormone receptor External Id：CHEMBL1018026

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