依吡哌唑

• 常用名: 依吡哌唑
• 英文名: Elopiprazole
• CAS号: 115464-77-2
• 分子量: 375.43900
• 密度: 1.269g/cm3
• 沸点: 542.8ºC at 760mmHg
• 分子式: C₂₃H₂₂FN₃O
• 熔点: N/A
• 闪点: 282.1ºC

依吡哌唑用途

Elopiprazole(DU 29840) 是一种抗神经病化合物,可用来研究神经系统疾病。

依吡哌唑名称

• 中文名: 依吡哌唑
• 英文名: 1-(1-benzofuran-7-yl)-4-[[5-(4-fluorophenyl)-1H-pyrrol-2-yl]methyl]piperazine

依吡哌唑生物活性

• 描述: Elopiprazole(DU 29840) 是一种抗神经病化合物,可用来研究神经系统疾病。
• 参考文献: 1. Crespo-Facorro B, et al. Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis. Front Pharmacol. 2021 Mar 2;12:646701.

依吡哌唑物理化学性质

• 密度: 1.269g/cm3
• 沸点: 542.8ºC at 760mmHg
• 分子式: C₂₃H₂₂FN₃O
• 分子量: 375.43900
• 闪点: 282.1ºC
• 精确质量: 375.17500
• PSA: 35.41000
• LogP: 4.89210
• InChIKey: PGNHBJGIQAEIHD-UHFFFAOYSA-N
• SMILES: Fc1ccc(-c2ccc(CN3CCN(c4cccc5ccoc45)CC3)[nH]2)cc1
• 蒸汽压: 7.65E-12mmHg at 25°C
• 折射率: 1.653

依吡哌唑靶点实验

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实验名称：Binding affinity for dopamine receptor D2 determined using [3H]spiperone 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL672308

实验名称：Suppression of conditioned avoidance behavior in rats after ip administration 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL883301

实验名称：Suppression of conditioned avoidance behavior in rats following p.o. administration. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779018

实验名称：Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]8-OH-DPAT a... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A External Id：CHEMBL616366

实验名称：Activity calculated as Na+ ratio [IC50 (+Na+) / IC50 (-Na+)] 来源：ChEMBL 靶标：N/A External Id：CHEMBL845721

实验名称：Potency to displace [3H]- WB-4101 from alpha-1 adrenergic receptor in rat striatum 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL645685

实验名称：Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL678340

实验名称：Potency to displace [3H]- Spiperone from 5-hydroxytryptamine 2 receptor in rat striat... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B External Id：CHEMBL617673

实验名称：Induction of catalepsy in rats when administered intraperitoneally 4 hr prior to meas... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779786

实验名称：Antagonism of apomorphine-induced climbing behavior in mice after peroral administrat... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL734147

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依吡哌唑英文别名

• 1-[5-(4-fluorophenyl)pyrrol-2-yl]methyl-4-(benzo[b]furan-7-yl)piperazine
• elopiprazole[inn]
• Elopiprazole
• UNII-419A0R564U
• 2-<<4-(7-benzofuranyl)-1-piperazinyl>methyl>-5-(4-fluorophenyl)pyrrole