cm-10-18

• 常用名: cm-10-18
• 英文名: cm-10-18
• CAS号: 1159614-57-9
• 分子量: 333.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₃₅NO₅
• 熔点: N/A
• 闪点: N/A

cm-10-18用途

CM-10-18是一种有效的ERα-葡萄糖苷酶抑制剂。CM-10-18对来自引起出血热的四个病毒家族的代表性病毒表现出优异的体外抗病毒活性。CM-10-18有效地保护了登革热病毒感染小鼠的致死性。

cm-10-18名称

• 英文名: CM-10-18

cm-10-18生物活性

• 描述: CM-10-18是一种有效的ERα-葡萄糖苷酶抑制剂。CM-10-18对来自引起出血热的四个病毒家族的代表性病毒表现出优异的体外抗病毒活性。CM-10-18有效地保护了登革热病毒感染小鼠的致死性。
• 参考文献: 1. Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, Butters TD, Bavari S, Xu X, Block TM. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res. 2013 Jun;98(3):432-40. doi: 10.1016/j.antiviral.2013.03.023. PubMed PMID: 23578725; PubMed Central PMCID: PMC3663898.

cm-10-18物理化学性质

• 分子式: C₁₇H₃₅NO₅
• 分子量: 333.46
• InChIKey: VLVMPUBHMJVGPH-QKPAOTATSA-N
• SMILES: CCC(O)(CC)CCCCCCN1CC(O)C(O)C(O)C1CO

cm-10-18靶点实验

查看更多实验

实验名称：Antiviral activity against 0.01 MOI DENV-2 NGC infected in BHK cells assessed as redu... 来源：ChEMBL 靶标：dengue virus type 2 External Id：CHEMBL2167912

实验名称：Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV NADL infected in MDB... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167913

实验名称：Selectivity index, ratio of CC50 for BHK cells to EC50 for DENV-2 NGC infected in BHK... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167910

实验名称：Cytotoxicity against BHK cells assessed as cell viability by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167911

实验名称：Inhibition of human CYP3A4 using testosterone as substrate at 10 uM 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL2167916

实验名称：Inhibition of human CYP2D6 at 10 uM 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL2167917

实验名称：Cytotoxicity against MDBK cells assessed as cell viability by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167914

实验名称：Antiviral activity against 1 MOI BVDV NADL infected in MDBK cells assessed as reducti... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2167915

实验名称：Antiviral activity against 0.01 MOI DENV infected in human Huh7.5 cells assessed as r... 来源：ChEMBL 靶标：Dengue virus External Id：CHEMBL2167904

实验名称：Metabolic stability in mouse liver microsomes at 60 mins 来源：ChEMBL 靶标：Liver External Id：CHEMBL2167905

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