PPTN

• 常用名: PPTN
• 英文名: PPTN
• CAS号: 1160271-30-6
• 分子量: 589.525
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₄F₃NO₂
• 熔点: N/A
• 闪点: N/A

PPTN用途

PPTN是P2Y14受体的有效,高度特异性的标记物,在功能测定中Ki为0.4nM；在1μM时对P2Y1,P2Y2,P2Y4,P2Y6,P2Y11,P2Y12或P2Y13受体没有表现出激动剂或拮抗剂作用；抑制UDP-葡萄糖刺激的人嗜中性粒细胞的趋化性。

PPTN名称

• 英文名: PPTN trifluoroacetate salt

PPTN生物活性

• 描述: PPTN是P2Y14受体的有效,高度特异性的标记物,在功能测定中Ki为0.4nM；在1μM时对P2Y1,P2Y2,P2Y4,P2Y6,P2Y11,P2Y12或P2Y13受体没有表现出激动剂或拮抗剂作用；抑制UDP-葡萄糖刺激的人嗜中性粒细胞的趋化性。
• 参考文献: References 1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168. 2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68. 3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42. 4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9. View Related Products by Target P2Y Receptor

PPTN物理化学性质

• 分子式: C₂₉H₂₄F₃NO₂
• 分子量: 589.525
• 精确质量: 589.168762
• InChIKey: FOECKIWHCOYYFL-UHFFFAOYSA-N
• SMILES: O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1

PPTN靶点实验

查看更多实验

实验名称：Solubility of compound in pH 7.4 PBS buffer vortex for 1 min followed by 10 mins soni... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4362031

实验名称：Inhibition of inflammasome in human THP1 cells assessed as reversal of MSU-induced co... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4362030

实验名称：Inhibition of inflammasome in human THP1 cells assessed as reversal of MSU-induced in... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4362028

实验名称：Inhibition of inflammasome in human THP1 cells assessed as reversal of MSU-induced in... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4362027

实验名称：Inhibition of pyroptosis in human THP1 cells assessed as inhibition of MSU-induced in... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4362036

实验名称：Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 ... 来源：ChEMBL 靶标：P2Y purinoceptor 14 External Id：CHEMBL4362018

实验名称：Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 ... 来源：ChEMBL 靶标：P2Y purinoceptor 14 External Id：CHEMBL4362017

实验名称：Inhibition of inflammasome in human THP1 cells assessed as reversal of MSU-induced in... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4362026

实验名称：Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 ... 来源：ChEMBL 靶标：P2Y purinoceptor 14 External Id：CHEMBL4189951

实验名称：Inhibition of pyroptosis in human THP1 cells assessed as inhibition of MSU-induced in... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4362022

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PPTN英文别名

• 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoic acid trifluoroacetate (1:1)
• 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid trifluoroacetate salt
• 2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-, compd. with 2,2,2-trifluoroacetic acid (1:1)
• PPTN trifluoroacetate salt