1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea

• 常用名: 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea
• 英文名: 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea
• CAS号: 1160934-75-7
• 分子量: 506.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₀N₈O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea

物理化学性质

• 分子式: C₂₉H₃₀N₈O
• 分子量: 506.6
• InChIKey: MWDKKNFEOXEAEC-UHFFFAOYSA-N
• SMILES: Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc(Nc3ncnc4ccc(N)cc34)c2)c1

靶点实验

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实验名称：Binding affinity to human CSK at 5 uM 来源：ChEMBL 靶标：Tyrosine-protein kinase CSK External Id：CHEMBL999779

实验名称：Binding affinity to human ROCK1 at 5 uM 来源：ChEMBL 靶标：Rho-associated protein kinase 1 External Id：CHEMBL999778

实验名称：Binding affinity to acrylodan-labeled cSrc assessed as dissociation half life at 100 ... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase Src External Id：CHEMBL995338

实验名称：Binding affinity to human AMPKalpha1 at 5 uM 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL999781

实验名称：Binding affinity to human ZAP70 at 5 uM 来源：ChEMBL 靶标：Tyrosine-protein kinase ZAP-70 External Id：CHEMBL999780

实验名称：Binding affinity to human RAF1 at 5 uM 来源：ChEMBL 靶标：RAF proto-oncogene serine/threonine-protein kinase External Id：CHEMBL999775

实验名称：Binding affinity to human BRAF V600E mutant at 5 uM 来源：ChEMBL 靶标：Serine/threonine-protein kinase B-raf External Id：CHEMBL999774

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Binding affinity to human BRAF at 5 uM 来源：ChEMBL 靶标：Serine/threonine-protein kinase B-raf External Id：CHEMBL999777

实验名称：Binding affinity to human CDK8 at 5 uM 来源：ChEMBL 靶标：Cyclin-dependent kinase 8 External Id：CHEMBL999776

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