SR-3737

• 常用名: SR-3737
• 英文名: SR-3737
• CAS号: 1164153-37-0
• 分子量: 512.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₅FN₄O₄
• 熔点: N/A
• 闪点: N/A

SR-3737用途

SR-3737是有效的JNK3和p38抑制剂。

SR-3737名称

• 英文名: SR-3737

SR-3737生物活性

• 描述: SR-3737是有效的JNK3和p38抑制剂。
• 参考文献: 1. Kamenecka T, Habel J, Duckett D, Chen W, Ling YY, Frackowiak B, Jiang R, Shin Y, Song X, LoGrasso P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. doi: 10.1074/jbc.M809430200. Epub 2009 Mar 4. PubMed PMID: 19261605; PubMed Central PMCID: PMC2676016.

SR-3737物理化学性质

• 分子式: C₂₉H₂₅FN₄O₄
• 分子量: 512.53
• InChIKey: GYQLVKWGHKBDMP-UHFFFAOYSA-N
• SMILES: COc1cc(NC(=O)c2cccc(-n3ncc4cc(Nc5ccccc5F)ccc43)c2)cc(OC)c1OC

SR-3737靶点实验

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实验名称：Inhibition of JNK3 (unknown origin)-mediated ATF2 Thr71 phosphorylation by HTRF assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 10 External Id：CHEMBL2379720

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2379715

实验名称：Half life in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2379714

实验名称：AUC in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2379713

实验名称：Plasma concentration in C57BL6 mouse at 10 mg/kg, ip after 2 hrs 来源：ChEMBL 靶标：Plasma External Id：CHEMBL2379712

实验名称：Inhibition of JNK1 (unknown origin)-mediated ATF2 Thr71 phosphorylation by HTRF assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 8 External Id：CHEMBL2379719

实验名称：Selectivity ratio of IC50 for JNK1 (unknown origin) to IC50 for JNK3 (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL2379718

实验名称：Inhibition of MAPK p38 (unknown origin)-mediated ATF2 Thr71 phosphorylation by HTRF a... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL2379717

实验名称：Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 10 External Id：CHEMBL3395898

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