R-(-)-度洛西汀

• 常用名: R-(-)-度洛西汀
• 英文名: (R)-Duloxetine
• CAS号: 116539-60-7
• 分子量: 333.875
• 密度: 1.158
• 沸点: 466.2ºC at 760 mmHg
• 分子式: C₁₈H₂₀ClNOS
• 熔点: N/A
• 闪点: 235.7ºC

R-(-)-度洛西汀用途

是一种5-羟色胺和去甲肾上腺素重摄取的双重抑制剂，能有效治疗抑郁症的情感和躯体症状

R-(-)-度洛西汀名称

• 中文名: 度洛西汀
• 英文名: (3R)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
• 中文别名: (R)-(-)-N-甲基-3-(1-萘氧基)-3-(2-噻吩)-丙胺 | 右旋度洛西汀盐酸盐

R-(-)-度洛西汀物理化学性质

• 密度: 1.158
• 沸点: 466.2ºC at 760 mmHg
• 分子式: C₁₈H₂₀ClNOS
• 分子量: 333.875
• 闪点: 235.7ºC
• 精确质量: 333.095398
• PSA: 49.50000
• LogP: 5.82380
• InChIKey: ZEUITGRIYCTCEM-QGZVFWFLSA-N
• SMILES: CNCCC(Oc1cccc2ccccc12)c1cccs1
• 储存条件: 2-8℃

R-(-)-度洛西汀靶点实验

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实验名称：Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4651404

实验名称：Inhibition of [3H]NE reuptake at human NET expressed in HEK cells 来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter External Id：CHEMBL1038443

实验名称：Inhibition of PDE4D2 assessed as cAMP hydrolysis 来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4D External Id：CHEMBL1038444

实验名称：Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cells 来源：ChEMBL 靶标：Sodium-dependent dopamine transporter External Id：CHEMBL1038441

实验名称：Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cells 来源：ChEMBL 靶标：Sodium-dependent serotonin transporter External Id：CHEMBL1038442

实验名称：Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation sp... 来源：ChEMBL 靶标：Transporter External Id：CHEMBL1014662

实验名称：Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells 来源：ChEMBL 靶标：Sodium-dependent serotonin transporter External Id：CHEMBL1038439

实验名称：Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liqu... 来源：ChEMBL 靶标：Sodium-dependent serotonin transporter External Id：CHEMBL1014663

实验名称：Displacement of [125I]RTI-55 from human recombinant NET expressed in HEK293 cells by ... 来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter External Id：CHEMBL1038440

实验名称：Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintil... 来源：ChEMBL 靶标：Sodium-dependent dopamine transporter External Id：CHEMBL1014661

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R-(-)-度洛西汀英文别名

• Cymbalta
• Ariclaim
• R-Duloxetine HCl
• (3R)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1)
• 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γR)-, hydrochloride (1:1)
• UNII-TK9VOT90JQ
• N-methyl-3-napthalen-1-oxy-3-thiophen-2-yl-1-amine